Chicks inoculated in the wing web with fixed rabies virus (RV) were protected against subsequent challenge injections of Rous sarcoma virus (RSV). The protection was transient, generalized and was not elicited in birds treated with actinomycin D or hydrocortisone. Chick serum was shown to possess a factor induced by RV, which inhibited RSV , and its presence in the serum at different times after RV administration was closely correlated with the RV-RSV blockade. This serum factor (SF), probably protein in nature, was heat and pH-labile. The inhibition of RSV by RV or the serum factor was affected by flock changes in a manner suggesting the occasional presence of interfering contaminating agent(s).


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