@article{mbs:/content/journal/jgv/10.1099/0022-1317-19-1-1, author = "Billiau, A. and Joniau, M. and De Somer, P.", title = "Mass Production of Human Interferon in Diploid Cells Stimulated by Poly-I:C", journal= "Journal of General Virology", year = "1973", volume = "19", number = "1", pages = "1-8", doi = "https://doi.org/10.1099/0022-1317-19-1-1", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-19-1-1", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY The production of interferon by human diploid cells stimulated by poly-I:C can be increased by pretreatment of the cells with interferon (priming effect). Large amounts of interferon (30000 units/ml) can be obtained by combining priming with a superinduction schedule adapted from that described for rabbit kidney cultures (Tan et al., 1970; Vilcek & Ng, 1971). Human plasma protein could replace bovine serum albumin in the production medium.", }