1887

Abstract

For practical purposes avian RNA tumour viruses have been divided into sarcoma and leukosis viruses. Sarcoma viruses have the ability to transform chick embryo fibroblasts and to induce fibro-sarcomas after a latent period of about 7 to 21 days. Leukosis viruses do not transform chick embryo fibroblasts, although they replicate in them, and most wild strains induce principally lymphoid leukosis after a latent period of over 90 days. They also frequently induce erythroid leukosis (erythroblastosis) and osteopetrosis, and occasionally other tumours.

Non-transforming mutants of sarcoma viruses, which have all the properties of leukosis viruses, have been produced experimentally by exposure to ultraviolet light (Toyoshima, Friis & Vogt, 1970), by γ-irradiation (Goldé, 1970) and by treatment with chemicals (Graf . 1971). These results suggest that leukosis viruses may originate from sarcoma viruses, perhaps by loss of genetic material either by mutation or by segregation of subgenomic components (Toyoshima . 1970; Graf . 1971; Martin & Duesberg, 1972). It has been suggested that non-transforming mutants arise spontaneously when cloned strains of Rous sarcoma viruses are grown (Vogt, 1971). However, regardless of whether such non-transforming viruses arise spontaneously or are produced experimentally, it is necessary to know whether they are oncogenic and behave like wild-type leukosis viruses.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-18-3-399
1973-03-01
2022-01-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/18/3/JV0180030399.html?itemId=/content/journal/jgv/10.1099/0022-1317-18-3-399&mimeType=html&fmt=ahah

References

  1. Biggs P. M., Payne L. N. 1964; The relationship of Marek’s disease (neuro-lymphomatosis) to lymphoid leukosis. National Cancer Institute Monograph 17:83–98
    [Google Scholar]
  2. Bolognesi D. P., Graf T. 1971; Size differences among the high molecular weight RNA’s of avian tumour viruses. Virology 43:214–222
    [Google Scholar]
  3. Burmester B. R., Fontes A. K., Waters N. F., Bryan W. R., Groupe V. 1960; The response of several inbred lines of white leghorn to inoculation with the viruses of strain RPL 12 visceral lymphomatosis-erythroblastosis and of Rous sarcoma. Poultry Science 39:199–215
    [Google Scholar]
  4. Duesberg P. H., Vogt P. K. 1970; Differences between the ribonucleic acids of transforming and nontransforming avian tumour viruses. Proceedings of the National Academy of Sciences of the United States of America 67:1673–1680
    [Google Scholar]
  5. Golde A. 1970; Radio induced mutants of the Schmidt-Ruppin strain of Rous sarcoma virus. Virology 40:1022–1029
    [Google Scholar]
  6. Graf T., Bauer H., Gelderblom H., Bolognesi D. P. 1971; Studies on the reproductive and cell-converting abilities of avian sarcoma viruses. Virology 43:427–441
    [Google Scholar]
  7. Kenzy S. G., Biggs P. M. 1967; Excretion of the Marek’s disease agent by infected chickens. Veterinary Record 80:565–568
    [Google Scholar]
  8. Kurth R., Bauer H. 1972; Cell-surface antigens induced by avian RNA tumour viruses: detection by a cytoxic microassay. Virology 47:426–433
    [Google Scholar]
  9. Martin G. S., Duesberg P. H. 1972; The a subunit in the RNA of transforming avian tumour viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in non-transforming variants. Virology 47:494–497
    [Google Scholar]
  10. Purchase H. G., Burmester B. R. 1972; Leukosis/sarcoma group. Diseases of Poultry, 6th edn.. pp. 502–568 Edited by Hofstad M. S. Ames, U.S.A.: The Iowa State University Press;
    [Google Scholar]
  11. Siccardi F. J., Burmester B. R. 1970; The differential diagnosis of lymphoid leukosis and Marek’s disease. United States Department of Agriculture. Agricultural Research Service Technical Bulletin, No. 1412
    [Google Scholar]
  12. Toyoshima K., Friis R. R., Voot P. K. 1970; The reproduction and cell-transforming capacities of avian sarcoma virus B. 77: inactivation with UV light. Virology 42:163–170
    [Google Scholar]
  13. Vogt P. K. 1971; Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses. Virology 46:939–946
    [Google Scholar]
  14. Weiss R. A., Friis R. R., Katz E., Vogt P. K. 1971; Induction of avian tumour viruses in normal cells by physical and chemical carcinogens. Virology 46:920–938
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-18-3-399
Loading
/content/journal/jgv/10.1099/0022-1317-18-3-399
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error