Much information regarding the association of the Epstein-Barr virus (EBV) with infectious mononucleosis, Burkitt’s lymphoma and nasopharyngeal carcinoma has been derived from serological test procedures, involving a number of distinct antigen-antibody systems related to EBV. These relationships have been recently reviewed (Henle & Henle, 1972).
DurrF. E.,
MonroeJ. H.,
SchmitterR.,
TraulK. A.,
HirshautY.1970; Studies on infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells. International Journal of Cancer 6:436–449
HenleW.,
HenleG.1972; Epstein-Barr virus: the cause of infectious mononucleosis. In Oncogenesis and Herpesviruses pp. 269–274 Edited by
BiggsP. M.,
De-TheG.,
PayneL. N.
Lyon: International Agency for Research on Cancer;
HenleG.,
HenleW.,
CliffordP.,
DiehlV.,
KafukoG. W.,
KiryaB. G.,
KleinG.,
MorrowR. H.,
MunubeG. M. R.,
PikeP.,
TukeiP.,
ZieglerJ.1969; Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups. Journal of National Cancer Institute 43:1147–1157
HenleG.,
HenleW.,
KleinG.1971; Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells. International Journal of Cancer 8:272–282
HenleW.,
HenleG.,
ZajacB. A.,
PearsonG.,
WaubkeR.,
ScribaM.1970; Differential reactivity of human serums with early antigens induced by Epstein-Barr virus. Science, New York 169:188–190
MillerG.,
NiedermanJ. C.,
StittD. A.1972; Infectious mononucleosis: appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines. Journal of Infectious Diseases 125:403–406
PearsonG.,
DeweyF.,
KleinG.,
HenleG.,
HenleW.1970; Relation between neutralization of Epstein-Barr virus and antibodies to cell-membrane antigens induced by the virus. Journal of the National Cancer Institute 45:989–995
RocchiG.,
HewetsonJ.,
HenleW.,
HenleG.1973; Antigen expression and colony formation of lymphoblastoid cell lines after super-infection with Epstein-Barr virus. Journal of the National Cancer Institute (in the press)