Transmission of Maternal Antibodies to Sendai Virus in Mice and its Significance in Enzootic Infection Free

Abstract

SUMMARY

Maternal antibodies to Sendai virus appeared to be transferred to newborn mice to a greater extent via colostrum and gastro-intestinal tract than via the placenta. Serum antibody reached a maximum within a week of birth and remained high for a few weeks before decreasing gradually. The immunoelectrophoretic analysis of serum globulins of suckling mice demonstrated IgG and IgG but no IgA, and suggested a selective transport of maternal globulins through the gastrointestinal epithelium of suckling mice. The maternal antibody effectively protected one-day-old newborn mice against intranasal challenge by a lethal dose of Sendai virus, but was less effective against the contact infection of 3-week-old mice. Thus, passive immunity appeared to be brief. Enzootic infections with Sendai virus are discussed on the basis of these experiments.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-18-3-247
1973-03-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/18/3/JV0180030247.html?itemId=/content/journal/jgv/10.1099/0022-1317-18-3-247&mimeType=html&fmt=ahah

References

  1. Brambell F. W. R. 1958; The passive immunity of the young mammal. Biological Reviews 33:488–531
    [Google Scholar]
  2. Brambell F. W. R., Hemmings W. A. 1960; The transmission of antibodies from mother to fetus. The Placenta and Fetal Membranes71–84 Edited by Villee C. A. Baltimore: Williams & Wilkens;
    [Google Scholar]
  3. Fahey J. L., Barth W. F. 1965; The immunoglobulins of mice. 4. Serum immunoglobulin changes following birth. Proceedings of Society of Experimental Biology and Medicine 118:596–600
    [Google Scholar]
  4. Fahey J. L., & Robinson A. G. 1963; Factors controlling serum y-globulin concentration. Journal of Experimental Medicine 118:845–868
    [Google Scholar]
  5. Fukumi H., Mizutani H., Takeuchi Y., Tajima Y., Imaizumi K., Tanaka T., Kaneko J. 1962; Studies On Sendai virus infection in laboratory mice. Japanese Journal of Medical Sciences and Biology 15:153–163
    [Google Scholar]
  6. Iida T. 1972; Experimental study on the transmission of Sendai virus in specific pathogen-free mice. Journal of General Virology 14:69–75
    [Google Scholar]
  7. Murata Y., Iida T. 1969; HVJ. Fluorescent Antibody Techniques and Their Applications109–114 Edited by Kawamura A. Tokyo: University of Tokyo Press;
    [Google Scholar]
  8. Nossal G. J. V. 1957; The immunological response of foetal mice to influenza virus. Australian Journal of Experimental Biology and Medical Science 35:549–558
    [Google Scholar]
  9. Van Nunen M. C. J., & Van Der Veen J. 1968; Experimental infection with Sendai virus in mice. Archiv fiir die gesamte Virusforschung 23:388–397
    [Google Scholar]
  10. Parker J. C., Tennant R. W., Ward T. G., Rowe W. P. 1964; Enzootic Sendai virus infection in mouse breeder colonies within the United States. Science, New York 146:936–938
    [Google Scholar]
  11. Sawicki L. 1961; Influence of age of mice on the recovery from experimental Sendai virus infection. Nature, London 192:1258–1259
    [Google Scholar]
  12. Sawicki L. 1962; Studies on experimental Sendai virus infection in laboratory mice. Acta virologica 6:347–351
    [Google Scholar]
  13. Scheidegger J. J. 1955; Une micro-methode l’immunelectrophorese. International Archieves of Allergy and Applied Immunology 7:103–110
    [Google Scholar]
  14. Uhr J. W., Baumann J. B. 1961; Antibody formation. I. The suppression of antibody formation by passively administered antibody. Journal of Experimental Medicine 113:935–957
    [Google Scholar]
  15. Wagner R. R. 1955; A pantropic strain of influenza virus: generalized infection and viremia in the infant mouse. Virology 1:497–515
    [Google Scholar]
  16. Wahren B. 1968; Immunotherapy in Friend virus leukemia. I. Prevention of Friend leukemia in the offspring of immunized mothers. Journal of National Cancer Institute 41:923–929
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-18-3-247
Loading
/content/journal/jgv/10.1099/0022-1317-18-3-247
Loading

Data & Media loading...

Most cited Most Cited RSS feed