@article{mbs:/content/journal/jgv/10.1099/0022-1317-18-3-247, author = "Iida, T. and Tajima, M. and Murata, Yuriko", title = "Transmission of Maternal Antibodies to Sendai Virus in Mice and its Significance in Enzootic Infection", journal= "Journal of General Virology", year = "1973", volume = "18", number = "3", pages = "247-254", doi = "https://doi.org/10.1099/0022-1317-18-3-247", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-18-3-247", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY Maternal antibodies to Sendai virus appeared to be transferred to newborn mice to a greater extent via colostrum and gastro-intestinal tract than via the placenta. Serum antibody reached a maximum within a week of birth and remained high for a few weeks before decreasing gradually. The immunoelectrophoretic analysis of serum globulins of suckling mice demonstrated IgG1 and IgG2 but no IgA, and suggested a selective transport of maternal globulins through the gastrointestinal epithelium of suckling mice. The maternal antibody effectively protected one-day-old newborn mice against intranasal challenge by a lethal dose of Sendai virus, but was less effective against the contact infection of 3-week-old mice. Thus, passive immunity appeared to be brief. Enzootic infections with Sendai virus are discussed on the basis of these experiments.", }