1887

Abstract

SUMMARY

Selenocystamine dihydrochloride (0.003 m) inhibited particle-associated -dependent polymerase activity of influenza B//40, influenza A//34 (H0 N1), A/-5 (), recombinant A/-5 () and recombinant A//68 (H2)-A/ (N1) . The structurally related compounds -cystine, cystamine and -diacetyl selenocystamine were less active and inhibited influenza B/ particle-associated -dependent polymerase activity by 50% at concentrations of >0.3, 0.3 and 0.018 m, respectively. Particle-associated -dependent polymerase activity was inhibited immediately by addition of selenocystamine. The inhibitory activity of 0.01 m-selenocystamine was reversed completely by the addition of 0.06 m-β-mercaptoethanol and partially by dialysis of a virus-selenocystamine mixture. High concentrations (3 m) of the compound had no detectable effect on influenza virus haemagglutinin or neuraminidase activities, but virus infectivity was reduced significantly after incubation with 0.03 m-selenocystamine.

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/content/journal/jgv/10.1099/0022-1317-18-1-11
1973-01-01
2021-10-20
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