Poly (A) segments form a part of mammalian mRNA (Darnell, 1971; Edmonds, Vaughan & Nakazato, 1971; Mendecki, Lee & Brawerman, 1972), vaccinia virus mRNA (Kates, 1970) and the RNA of a number of RNA viruses (Armstrong 1972; Gillespie, Marshall & Gallo, 1972; Johnston & Bose, 1972; Lai & Duesberg, 1972). The potential significance of the poly (A) segment in mRNA function is unknown, but it is of interest that the genomes of RNA tumour viruses contain a much greater proportion of poly (A) than the RNAs of other viruses and that poly (A) segments have not been detected in virus RNAs that do not function directly as mRNA, such as the RNAs of influenza virus, Newcastle disease virus and vesicular stomatitis virus (Gillespie 1972; Lai & Duesberg, 1972). It has been reported that the poly (A) segment of poliovirus RNA represents 0.75% (Armstrong 1972) or 0.25% (Gillespie 1972) of the total nucleotide content of the virus genome.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error