1887

Abstract

SUMMARY

Poly (A) segments form a part of mammalian mRNA (Darnell, 1971; Edmonds, Vaughan & Nakazato, 1971; Mendecki, Lee & Brawerman, 1972), vaccinia virus mRNA (Kates, 1970) and the RNA of a number of RNA viruses (Armstrong 1972; Gillespie, Marshall & Gallo, 1972; Johnston & Bose, 1972; Lai & Duesberg, 1972). The potential significance of the poly (A) segment in mRNA function is unknown, but it is of interest that the genomes of RNA tumour viruses contain a much greater proportion of poly (A) than the RNAs of other viruses and that poly (A) segments have not been detected in virus RNAs that do not function directly as mRNA, such as the RNAs of influenza virus, Newcastle disease virus and vesicular stomatitis virus (Gillespie 1972; Lai & Duesberg, 1972). It has been reported that the poly (A) segment of poliovirus RNA represents 0.75% (Armstrong 1972) or 0.25% (Gillespie 1972) of the total nucleotide content of the virus genome.

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/content/journal/jgv/10.1099/0022-1317-17-3-349
1972-12-01
2022-01-28
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References

  1. Armstrong J. A., Edmonds M., Nakazato H., Philips B. A., Vaughan M. H. 1972; Polyadenylic add sequences in the virion RNA of poliovirus and eastern equine encephalitis virus. Science, New York 176:526–528
    [Google Scholar]
  2. Darnell J. E., Philipson L., Wall R., Adesnik M. 1971; Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science, New York 174:507–510
    [Google Scholar]
  3. Edmonds M., Vaughan M. H., Nakazato H. 1971; Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship. Proceedings of the National Academy of Sciences of the United States of America 68:1336–1340
    [Google Scholar]
  4. Gillespie D., Marshall S., Gallo R. C. 1972; RNA of RNA tumor viruses contains poly (A). Nature New Biology 236:227–231
    [Google Scholar]
  5. Johnston R. E., Bose H. R. 1972; An adenylate-rich segment in the virion RNA of Sindbis virus. Biochemical Biophysical Research Communications 46:712–718
    [Google Scholar]
  6. Kates J. 1970; Transcription of the vaccinia virus genome and the occurrence of polyriboadenylic acid sequences in messenger RNA. Cold Spring Harbor Symposia on Quantitative Biology 35:743–752
    [Google Scholar]
  7. Kerr I., Martin E. M. 1972; Simple method for the isolation of encephalomyocarditis virus ribonucleic acid. Journal of Virology 9:559–561
    [Google Scholar]
  8. Lai M. M. C., Duesberg P. H. 1972; Adenylic acid-rich sequences in RNAs of Rous sarcoma virus and Rauscher mouse leukemia virus. Nature, London 235:383–386
    [Google Scholar]
  9. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  10. Martin R. O., Ames B. N. 1961; A method for determining the sedimentation behavior of enzymes. Application to protein mixtures. Journal of Biological Chemistry 236:1372–1379
    [Google Scholar]
  11. Mendecki J., Lee S. Y., Brawerman G. 1972; Characteristics of the polyadenylic acid segment associated with messenger ribo-nucleic acid in mouse sarcoma 180 ascites cells. Biochemistry 11:792–797
    [Google Scholar]
  12. Plagemann P. G. W. 1968; Mengovirus replication in Novikoff rat hepatoma and mouse L cells: Effects on the synthesis of host-cell macromolecules and virus-specific synthesis of ribonucleic acid. Journal of Virology 2:461–473
    [Google Scholar]
  13. Plagemann P. G. W. 1970; Temperature- and phenol-induced alterations in sedimentation rates of 29-S and 18-S ribosomal RNA’s from Novikoff hepatoma cells. Biochimica et biophysica acta 224:451–457
    [Google Scholar]
  14. Plagemann P. G. W. 1972; Nucleotide pools in Novikoff rat hepatoma cells growing in suspension culture. III. Effects of nucleosides in medium on levels of nucleotides in separate nucleotide pools for nuclear and cytoplasmic RNA synthesis. Journal of Cell Biology 52:131–146
    [Google Scholar]
  15. Plagemann P. G. W., Swim H. E. 1966; Replication of mengovirus. I. Effect on synthesis of macromolecules by host cell. Journal of Bacteriology 91:2317–2326
    [Google Scholar]
  16. Plagemann P. G. W., Swim H. E. 1968; Synthesis of ribonucleic acid by mengovirus-induced RNA polymerase in vitro: nature of products and of RNase-resistant intermediate. Journal of Molecular Biology 35:13–35
    [Google Scholar]
  17. Spirin A. S. 1963; Some problems concerning the macromolecular structure of ribonucleic acids. Progress in Nucleic Acid Research 1:301–345
    [Google Scholar]
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