RT Journal Article SR Electronic(1) A1 Barlati, S. A1 Vigier, P.YR 1972 T1 Effect of Two Rifamycin Derivatives on the Rous Sarcoma Virus Transformation System JF Journal of General Virology, VO 17 IS 2 SP 221 OP 225 DO https://doi.org/10.1099/0022-1317-17-2-221 PB Microbiology Society, SN 1465-2099, AB Replication of RNA tumour viruses appears to involve a DNA intermediate (provirus), as was postulated by Temin (1964) and is suggested notably by the discovery of virus-associated RNA-dependent DNA polymerase able to transcribe virus RNA into DNA (Baltimore, 1970; Duesberg & Canaani, 1970; Green et al. 1970; Mizutani & Temin, 1970; Spiegelman et al. 1970) and the recent finding, in RSV-transformed cells, of infectious DNA able to prime virus production in permissive cells (Hill & Hillova, 1971, 1972; Montagnier & Vigier, 1972). New rifamycin derivatives have now been synthesized which are powerful inhibitors of the RNA-dependent DNA polymerase of murine sarcoma virus (MSV) (Gurgo, Ray & Green, 1972). Especially active are the 3-oxime derivatives such as AF/05 and AF/013 which also have been shown to inhibit DNA-dependent RNA polymerase by preventing initiation of the RNA chains (Butterworth, Cox & Chesterton, 1971; Meilhac, Tysper & Chambon, 1972)., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-17-2-221