%0 Journal Article %A Kassanis, B. %A White, R. F. %T Interference between Two Satellite Viruses of Tobacco Necrosis Virus %D 1972 %J Journal of General Virology, %V 17 %N 2 %P 177-183 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-17-2-177 %I Microbiology Society, %X SUMMARY The tobacco necrosis satellite viruses SV1 and SV2 interfere with one another’s replication, and the larger the dose of the interfering satellite the greater the degree of interference produced. The amount of interference also depends on the strain of tobacco necrosis virus (TNV) used as helper. Suppression of SV2 by SV1 is greater than that of SV1 by SV2, although SV2 is the more infective. SVc differs serologically from SV1 and SV2 no more than these two differ from each other, but it needs a different strain of TNV for replication. Nevertheless, there is no interference between SVc and either SV1 or SV2. The interference between SV1 and SV2 takes place in the first 2 h after inoculation. Satellite viruses inoculated 3 days after TNV do not interfere with one another provided the TNV strain is one that aids their multiplication. The results suggest that SV1 and SV2 compete for an early metabolite. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-17-2-177