RT Journal Article SR Electronic(1) A1 Poste, G. A1 Reeve, P. A1 Alexander, D. J. A1 Terry, G.YR 1972 T1 Studies on the Cytopathogenicity of Newcastle Disease Virus: Effect of Lectins on Virus Infected Cells JF Journal of General Virology, VO 17 IS 1 SP 81 OP 89 DO https://doi.org/10.1099/0022-1317-17-1-81 PB Microbiology Society, SN 1465-2099, AB SUMMARY The infection of chick embryo (CE) and baby hamster kidney (BHK) cells with Newcastle disease virus (NDV) strains herts, warwick, texas, field pheasant, lamb essex or beaudette c increased their susceptibility to agglutination by the lectins, concanavalin A (Con A) and wheat germ agglutinin (WGA). The agglutination reaction with Con A and WGA was inhibited by α-methyl-d-glucopyranoside and N-acetyl-glucosamine, respectively. The agglutination of purified virus particles from these strains by the lectins indicated that lectin-receptors on the cell surface were incorporated into the virus envelope. A correlation was found between the change in cell agglutination behaviour after infection and the virus-induced alterations of the cell coat material. In contrast, CE and BHK cells infected with the avirulent queensland or ulster strains of NDV were not agglutinated by Con A or WGA and no changes were detected in the cell coat material. The greater susceptibility to agglutination by lectins found for cells infected with the more virulent NDV strains required the synthesis of virusinduced proteins. The relationship between agglutination and changes in the cell coat material is discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-17-1-81