1887

Abstract

Summary

Reports by others have described the haemagglutinins of Hong Kong (H3N2) strains and the Asian (H2N2) strains as being antigenically unrelated. Cross reactions seen by the haemagglutination-inhibition (HI) test have been attributed to antibodies to a second major surface antigen, the neuraminidase, which is common to both subtypes. However, observations on human anamnestic antibody responses suggest the two haemagglutinins are related. In the present study we reexamined the antigenic relationship of these viruses using haemagglutinin specific virus recombinants, chicken and ferret antisera, antibody equilibrium filtration methods, and cross-infection in ferrets. Data from these studies consistently demonstrated an asymmetric relationship, independent of the neuraminidase, between the H2 and H3 strains.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-16-2-127
1972-08-01
2019-10-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-16-2-127
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error