1887

Abstract

Serotypes of human adenovirus have been classified by Huebner (1967) into three groups (A, B and C) based on their oncogenicity in hamsters. Rat cells transformed by viruses from both groups A and B have been reported to produce tumours in new-born rats (Freeman 1967). Some members of Huebner's non-oncogenic group C were subsequently shown to cause morphological transformation of primary rat embryo cells (Freeman 1967; McAllister 1969). Clones derived from these epithelioid foci are similar in their characteristics to transformed clones induced by adenovirus in groups A and B. The cells grow to high density in medium with low serum, produce colonies in agar and possess adenovirus specific tumour antigen (T-antigen). No tumours were produced when cells transformed by the group C adenoviruses were inoculated into syngeneic neonate rats and it has been suggested that group C adenoviruses induce strong transplantation antigens in the cells they transform (McAllister 1969).

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/content/journal/jgv/10.1099/0022-1317-16-1-99
1972-07-01
2024-04-20
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References

  1. ALLISON A. C, BERMAN L. D., LEVEY R. H. 1967; Increased tumour induction by adenovirus type 12 in thymectomized mice and mice treated with antilymphocyte serum. Nature, London 215:185
    [Google Scholar]
  2. BALNER H., DERSJANT H. 1969; Increased oncogenic effect of methylcholanthrene after treatment with antilymphocyte serum. Nature, London 224:376
    [Google Scholar]
  3. CERILLI G. J., TREAT R. C. 1969; The effect of antilymphocyte serum on the induction and growth of tumour in the adult mouse. Transplantation 8:774
    [Google Scholar]
  4. FREEMAN A. E., BLACK P. H., VANDERPOOL E. A., HENRY P. H., AUSTIN J. B., HUEBNER R. J. 1967a; Transformation of primary rat embryo cells by adenovirus type 2. Proceedings of the National Academy of Sciences of the United States of America 58:1205
    [Google Scholar]
  5. FREEMAN A. E., BLACK P. H., WALFORD R., HUEBNER R. J. 1967e; Adenovirus type-12 rat embryo transformation system. Journal of Virology 1:362
    [Google Scholar]
  6. FREEMAN A. E., VANDERPOOL E. A., BLACK P. H., TURNER H. C., HUEBNER R. J. 1967c; Transformation of primary rat embryo cells by a weakly oncogenic adenovirus-type 3. Nature, London 316:171
    [Google Scholar]
  7. HUEBNER R. J. 1967 Adenovirus-directed tumour and T antigens. Perspectives in Virology v147 Ed. by Pollard M. New York: Academic Press Inc;
    [Google Scholar]
  8. McALLISTER R. M., NICOLSON M. O., LEWIS A. M., MacPherson I., HUEBNER R. J. 1969; Transformation of rat embryo cells by adenovirus type 1. Journal of General Virology 4:29
    [Google Scholar]
  9. SJöGREN H. O., BORUM K. 1971; Tumour-specific immunity in the course of primary Polyoma and Rous tumour development in intact and immunosuppressed rats. Cancer Research 31:890
    [Google Scholar]
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