Infection of chick embryo and baby hamster kidney cells with the virulent Newcastle disease virus (NDV) strains and and the mesogenic strain produced a significant reduction in the thickness of the cell coat material. There was a temporal relationship between the reduction in coat thickness, the formation of polykaryocytes by cell fusion, and the release of lysosomal enzymes in cells infected with these strains. No reduction in coat thickness was found in cells infected with the avirulent strains, and , which did not produce cell fusion. Little lysosomal enzyme release was found in cells infected with these strains. Cell fusion and the reduction in coat thickness in cells infected with the virulent strains were inhibited by treatment of infected cells with anti-NDV serum without impairment of virus replication.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error