1887

Abstract

Summary

Infection of chick embryo and baby hamster kidney cells with the virulent Newcastle disease virus (NDV) strains and and the mesogenic strain produced a significant reduction in the thickness of the cell coat material. There was a temporal relationship between the reduction in coat thickness, the formation of polykaryocytes by cell fusion, and the release of lysosomal enzymes in cells infected with these strains. No reduction in coat thickness was found in cells infected with the avirulent strains, and , which did not produce cell fusion. Little lysosomal enzyme release was found in cells infected with these strains. Cell fusion and the reduction in coat thickness in cells infected with the virulent strains were inhibited by treatment of infected cells with anti-NDV serum without impairment of virus replication.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-15-3-219
1972-06-01
2024-12-07
Loading full text...

Full text loading...

/deliver/fulltext/jgv/15/3/JV0150030219.html?itemId=/content/journal/jgv/10.1099/0022-1317-15-3-219&mimeType=html&fmt=ahah

References

  1. Alexander D. J., Reeve P., Allan W. H. 1970; Characterization and biological properties of the neuraminidases of strains of Newcastle disease virus which differ in virulence. Microbios 2:155
    [Google Scholar]
  2. Allison A. C. 1967; Lysosomes in virus infected cells. Perspectives in Virology 5:29
    [Google Scholar]
  3. Allison A. C. 1968; The role of lysosomes in the action of drugs and hormones. Advances in Chemotherapy 3:253
    [Google Scholar]
  4. Ejercito P. M., Kieff E. D., Roizman B. 1968; Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. Journal of General Virology 2:357
    [Google Scholar]
  5. Keller J. M., Spear P. O., Roizman B. 1970; Proteins specified by herpes simplex virus. III. Viruses differing in their effects on the social behaviour of infected cells specify different membrane glycoproteins. Proceedings of the National Academy of Sciences of the United States of America 65:865
    [Google Scholar]
  6. Poste G. 1970a; The measurement of cell surface glycoprotein coat materials by ellipsometry. 1. The technique. Cytobios 2:233
    [Google Scholar]
  7. Poste G. 1970b; Virus-induced polykaryocytosis and the mechanism of cell fusion. Advances in Virus Research 16:303
    [Google Scholar]
  8. Poste G. 1971a; Tissue dissociation with proteolytic enzymes: adsorption and activity of enzymes at the cell surface. Experimental Cell Research 65:359
    [Google Scholar]
  9. Poste G. 1971b; The role of lysosomes in virus-induced cell fusion. 2. Modification of the cell surface. Microbios 3:105
    [Google Scholar]
  10. Poste G., Allison A. C. 1971; The membrane fusion reaction: a theory. Journal of Theoretical Biology 32:165
    [Google Scholar]
  11. Reeve P., Alexander D. J. 1970; Plaque formation, cell fusion and haemadsorption by Newcastle disease virus. Cytobios 2:55
    [Google Scholar]
  12. Reeve P., Poste G. 1971; Studies on the cytopathogenicity of Newcastle disease virus: relation between virulence, polykaryocytosis and plaque size. Journal of General Virology n:17
    [Google Scholar]
  13. Reeve P., Waterson A. P. 1970; The growth cycle of avirulent strains of Newcastle disease virus. Microbios 2:5
    [Google Scholar]
  14. Reeve P., Rosenblum M., Alexander D. J. 1970; Growth in chick chorioallantoic membranes of strains of Newcastle disease virus of differing virulence. Journal of Hygiene, Cambridge 68:61
    [Google Scholar]
  15. Reeve P., Alexander D. J., Pope G., Poste G. 1971; Studies on the cytopathic effects of Newcastle disease virus: metabolic requirements. Journal of General Virology n:25
    [Google Scholar]
  16. Roizman B. 1970; Herpes viruses, membranes and the social behaviour in infected cells. Proceedings 3rd International Symposium on Applied and Medical Virology p. 37 St Louis: Warren Green Publishers;
    [Google Scholar]
  17. Roizman B., Spear P. G. 1971; The role of herpes virus glycoproteins in the modification of membranes of infected cells. Proceedings of the Symposium of Biochemistry Amsterdam: North Holland: (In the Press)
    [Google Scholar]
  18. Waterson A. P., Pennington T. H., Allan W. H. 1967; Virulence in Newcastle disease virus. A preliminary study. British Medical Bulletin 23:138
    [Google Scholar]
  19. W.H.O. Expert Committee On Influenza (1953). Technical Report Series of World Health Organization no. 64
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-15-3-219
Loading
/content/journal/jgv/10.1099/0022-1317-15-3-219
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error