1887

Abstract

Seven serologically and immunologically distinct types of foot-and-mouth disease virus (FMDV) are known; these types can be subdivided into numerous subtypes. Recently, we reported on polynucleotide sequence homologies among the ribonucleic acids (RNA’s) of FMDV types A, O and C (Dietzschold 1971). Making use of saturation and competition experiments various degrees (44 to 65%) of base sequence homologies between different types were obtained. This report is concerned with similar studies but using subtypes and mutants of FMDV, type O. We felt that there is a need especially for quantitative data on genetic relationships between different subtypes, because the serological classification is not always congruent with a classification based on immunological properties (Wittmann, 1964). Furthermore, it appeared interesting to compare in cross-annealing experiments wild-type virus with mutants reacting identically in serological tests.

The experiments were performed with radioactive labelled FMDV RNA of five O-subtypes and five mutants of subtype O which were hybridized with denatured unlabelled FMDV-specific double-stranded RNA of the respective virus-strains.

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1972-05-01
2022-07-02
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References

  1. Bachrach H. L. 1960; Ribonucleic acid of foot- and-mouth disease virus: its preparation, stability and plating efficiency on bovine kidney cultures. Virology 12:258
    [Google Scholar]
  2. Colby C., Duesberg P. M. 1969; Double-stranded RNA in vaccinia virus-infected cells. Nature, London 222:940
    [Google Scholar]
  3. Dietzschold B., Kaaden O. R., Tokui T., Böhm H. O. 1971; Polynucleotide sequence homologies among the RNAs of foot- and-mouth disease virus types A, C and O. The Journal of General Virology 13:1
    [Google Scholar]
  4. Hobson D., Scholtissek C. 1970; Hybridization studies with the RNA of the ws strain of influenza virus and its neurotropic variant nws. The Journal of General Virology 9:1
    [Google Scholar]
  5. Kaaden O. R., Eissner G., Böhm H. O. 1970; Untersuchungen über Maul-und Klauenseuche (MKS)-Virusdauerausscheider bei vakzinierten und experimentell infizierten Rindern. Zentralblatt für Veterinärmedizin, Reihe B, Band 17:485
    [Google Scholar]
  6. Rouminantzeff M., Stellmann C., Dubouclard C. 1965; Technique de fixation quantitative du complément appliquée à l’étude du virus de la fièvre aphteuse. Bulletin de la Société des Sciences Vétérinaires et de Médecine comparée de Lyon 67:243
    [Google Scholar]
  7. Wittmann G. 1964; Subtypen des Maul-und Klauenseuchevirus vom Typ O. Ihre antigenen und immuno-logischen Eigenschaften und Beziehungen zueinander. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, I. Originate 194:1
    [Google Scholar]
  8. Wittmann G., Ahl R. 1964; Genetische Merkmale attenuierter Maul-und Klauenseuche-Virusstämme. Office International des Epizooties, Bulletin 61:579
    [Google Scholar]
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