It has been shown with 23 lines of stable cells and five primary cell cultures that pronounced alkaline phosphatase activity (Ph marker) is associated with high susceptibility of cells to Coxsackie B viruses, while low activity is accompanied by resistance of the cells to Coxsackie B viruses. An exception was the primary culture of M rhesus kidney cells which was completely destroyed following Coxsackie B virus infection, although phosphatase-positive cells constituted only isolated groups in the culture. The brown fat of suckling mice, which are susceptible to Coxsackie B viruses, is composed of Ph-positive cells, while in Coxsackie B-resistant adult mice the tissue consists of Ph-negative elements. The data obtained are discussed with respect of a possible inter-relationship between presence of the enzyme activity and specific cellular sensitivity to the particular virus.


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