1887

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Volume 14, Issue 3

Mechanism of Enhanced Plaque Formation by Poliovirus in Poxvirus-Infected Cells Free

Abstract

SUMMARY

The mechanism of the enhancement by Yaba virus (YV) of poliovirus plaque formation was studied. Poliovirus adsorbed equally well to both YV-infected and normal JINET cells. Infectious RNA of poliovirus was also enhanced in YV-infected cells, thus indicating the step or sequence of steps of poliovirus growth cycle enhanced by YV may be those subsequent to poliovirus uncoating. One-step growth experiments revealed that the final yield and the release of progeny poliovirus were enhanced in YV-infected cells. This may account for the enhancement of the plaque size of poliovirus. The enhancement of the plaque number of the super-infecting virus by YV appeared to result from the interaction between a single YV-infected cell and a single infecting polio virus genome which failed to express its function under ordinary conditions. This enhancement may be brought about by the disturbance by YV of a host cellular defence mechanism other than that mediated by interferon.

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© Journal of General Virology 1972
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1972-03-01
2024-04-25
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References

  1. Kato S., Ogawa M., Miyamoto H. 1964; Nucleocytoplasmic interactions in poxvirus infected cells. I. Relationship between inclusion formation and DNA metabolism of the cells. Biken’s Journal 7:45
     [Google Scholar]
  2. Kit S., Dubbs D. R. 1962; Biochemistry of vaccinia-infected mouse fibroblasts (strain l-m). I. Effects on nucleic acid and protein synthesis. Virology 18:274
     [Google Scholar]
  3. Moss B. 1968; Inhibition of HeLa cell protein synthesis by the vaccinia virion. Journal of Virology 2:1028
     [Google Scholar]
  4. Shatkin A. I. 1963; Actinomycin D and vaccinia virus infection in HeLa cells. Nature, London 199:357
     [Google Scholar]
  5. Tsuchiya Y., Tagaya I. 1970; Enhanced or inhibited plaque formation of superinfecting viruses in Yaba virus-infected cells. Journal of General Virology 7:71
     [Google Scholar]
  6. Tsuchiya Y., Tagaya I. 1972; General characteristics of enhanced plaque formation by poliovirus in poxvirus-infected cells. Journal of General Virology 14:229
     [Google Scholar]
  7. Vaheri A., Pagano J. S. 1965; Infectious poliovirus RNA: A sensitive method of assay. Virology 27:434
     [Google Scholar]
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Mechanism of Enhanced Plaque Formation by Poliovirus in Poxvirus-Infected Cells
J. Gen. Virol. 14, 237 (1972); https://doi.org/10.1099/0022-1317-14-3-237
/content/journal/jgv/10.1099/0022-1317-14-3-237
/content/journal/jgv/10.1099/0022-1317-14-3-237
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