1887

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Volume 14, Issue 3

Mechanism of Enhanced Plaque Formation by Poliovirus in Poxvirus-Infected Cells Free

Abstract

SUMMARY

The mechanism of the enhancement by Yaba virus (YV) of poliovirus plaque formation was studied. Poliovirus adsorbed equally well to both YV-infected and normal JINET cells. Infectious RNA of poliovirus was also enhanced in YV-infected cells, thus indicating the step or sequence of steps of poliovirus growth cycle enhanced by YV may be those subsequent to poliovirus uncoating. One-step growth experiments revealed that the final yield and the release of progeny poliovirus were enhanced in YV-infected cells. This may account for the enhancement of the plaque size of poliovirus. The enhancement of the plaque number of the super-infecting virus by YV appeared to result from the interaction between a single YV-infected cell and a single infecting polio virus genome which failed to express its function under ordinary conditions. This enhancement may be brought about by the disturbance by YV of a host cellular defence mechanism other than that mediated by interferon.

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© Journal of General Virology 1972
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1972-03-01
2023-09-30
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References

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Mechanism of Enhanced Plaque Formation by Poliovirus in Poxvirus-Infected Cells
J. Gen. Virol. 14, 237 (1972); https://doi.org/10.1099/0022-1317-14-3-237
/content/journal/jgv/10.1099/0022-1317-14-3-237
/content/journal/jgv/10.1099/0022-1317-14-3-237
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