1887

Abstract

Summary

The primary immune response to sheep erythrocytes of spleen cells cultured from mice infected with Friend virus was compared with that of normal spleen cell cultures. Significant depression of the response, as measured by the production of haemolytic plaque-forming cells, was first observed when mice had been infected for 3 days prior to cell culture. This depression became more severe as the infection period was prolonged.

After 4 days infection the peak of the response was reduced to a mean of 11% of normal values. No depression was observed during the first 48 hr of the development of the response in such cultures.

The immune defect was shown to exist only in the non-adherent (lymphocyte-like) fraction of the spleen.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-14-1-77
1972-01-01
2019-10-17
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-14-1-77
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error