1887

Abstract

Summary

The inactivation of Semliki Forest virus in solutions of guanidine hydrochloride and urea shows an anomalous dependence on concentration. Under some circumstances the inactivation is reversible. This reactivation is non-cooperative and extracellular and can be induced by incubation at high, or at negligible inactivant concentrations. It is suggested that changes in the surface structure of the virus particle take place before or during inactivation and that modifications of the conformation of the virus are involved in the reversible reactions.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-13-3-393
1971-12-01
2019-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-13-3-393
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error