1887

Abstract

Summary

Semliki Forest virus was thermally inactivated between 20° and 50° by two processes, one of which predominated at temperatures below 41° and the other at higher temperatures. At pH 6.5, the rates of inactivation were greater than at pH 7.5 but the nature of the reactions was unchanged. The stability of the virus in phosphate buffer solutions was greatly reduced at lower concentrations of protein in the suspending medium. The rate of inactivation was reduced in the dark. At higher temperatures, a change occurred in the surface properties of the virus that did not, of itself, cause loss of infectivity.

It is suggested that at the higher temperatures the inactivation was a consequence of a structural breakdown of a surface unit in the virus; at lower temperatures a more subtle change in the substructure was responsible for inactivation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-13-3-385
1971-12-01
2019-12-08
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-13-3-385
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error