%0 Journal Article %A Docherty, J. J. %A O’Neill, F. J. %A Rapp, F. %T Differential Susceptibility to Herpes Simplex Viruses of Hamster Cell Lines Established after Exposure to Chemically Inactivated Herpesvirus %D 1971 %J Journal of General Virology, %V 13 %N 3 %P 377-384 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-13-3-377 %I Microbiology Society, %X SUMMARY The replication of herpes simplex virus type 1 and herpes simplex virus type 2 was studied in two isolated hamster cell lines. These lines developed after being treated with herpes simplex virus type 2 inactivated with 7,12-dimethylbenz(a)-anthracene. One cell line that developed, HDC-22, had a hypodiploid chromosome number and was missing a D-group chromosome. Growth studies revealed that this cell line did not support the replication of herpes simplex virus type 2 but did support the replication of herpes simplex virus type 1. The other cell line, HDC-17, had a normal karyotype and proved susceptible to both herpes simplex virus type 1 and herpes simplex virus type 2. These hamster cell lines afford an opportunity to study specific resistance to herpes simplex virus and the differences in the replicative cycles of type 1 and type 2 herpesviruses. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-13-3-377