Cells from crossbred embryos from the inbred Reaseheath R and W lines, which were segregating at the tva and tvb loci, and at a possible third locus, tvc, were examined for responses to avian sarcoma viruses of subgroups A, B and C. Responses to subgroup A were independent of those to subgroup B, as were those for subgroups B and C. Genetic analysis of the results suggested absence of linkage between the tvb locus and the tva or tvc loci.
Responses to subgroup A and C viruses were strongly associated and were consistent with linkage between the tva and tvc loci, or with the presence of a single locus which controlled responses to both subgroups.
CrittendenL. B.,
OkazakiW.1965; Genetic influence of the Rs locus on susceptibility to avian tumour viruses. I. Neoplasms induced by RPL12 and three strains of Rous sarcoma virus. Journal of the National Cancer Institute 35:857
CrittendenL. B.,
StoneH. A.,
ReamerR. H.,
OkazakiW.1967; Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. Journal of Virology 1:898