RT Journal Article SR Electronic(1) A1 Guir, J. A1 Braunwald, Jacqueline A1 Kirn, A.YR 1971 T1 Inhibition of Host-specific DNA and RNA Synthesis in KB Cells Following Infection with Frog Virus 3 JF Journal of General Virology, VO 12 IS 3 SP 293 OP 301 DO https://doi.org/10.1099/0022-1317-12-3-293 PB Microbiology Society, SN 1465-2099, AB SUMMARY In KB cells infected with frog virus 3 at 37°, a non-permissive temperature for frog virus 3, there was a marked inhibition of host-cell RNA and DNA synthesis shortly after infection. The inhibition, which was as effective with gamma-irradiated or heat-inactivated virus as with live frog virus 3 was dependent upon the multiplicity of infection with frog virus 3. The effect of frog virus 3 could not be abolished by chemical inhibitors of protein and RNA synthesis. These findings suggested that a component of the virus particle was responsible for the inhibition of host-cell RNA and DNA synthesis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-12-3-293