Adenovirus-induced Chromosome Aberrations in Human Cells Free

Abstract

SUMMARY

Infection of primary human embryo kidney cells with adenovirus types 2, 7, 12, 18 and 31, at a multiplicity of infection of 2, resulted in the induction of chromosome aberrations in metaphases examined 24 hr after infection. The aberrations induced by types 2 and 7 were randomly distributed over the karyotype, but types 12 and 31, and to a lesser extent type 18, all induced non-random effects. Both type 12 and type 31 produced chromatid and isochromatid gaps and breaks at a specific site on chromosome no. 17.

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1971-07-01
2024-03-28
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References

  1. Darbyshire J. H. 1966; Oncogenicity of bovine adenovirus type 3 in hamsters. Nature, London 211:102
    [Google Scholar]
  2. Evans H. J. 1967; Dose response relations from in vitro studies. In Human Radiation Cytogenetics p 20 Ed. by Evans J. H. Court-Brown W. M., McLean A. S. Amsterdam: North Holland Publishing Company;
    [Google Scholar]
  3. Ferguson-Smith M. A. 1962; The identification of human chromosomes. Proceedings of the Royal Society of Medicine 55:471
    [Google Scholar]
  4. Freeman A. E., Black P. H., Vanderpool E. A., Henry P. H., Austin J. B., Huebner R. J. 1967; Transformation of primary rat embryo cells by adenovirus type 2. Proceedings of the National Academy of Sciences of the United States of America 58:1205
    [Google Scholar]
  5. Ham R. G. 1963; An improved nutrient solution for diploid Chinese hamster and human cell lines. Experimental Cell Research 29:515
    [Google Scholar]
  6. Huang C. C. 1967; Induction of a high incidence of damage to the X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses and carcinogens. Chromosoma (Berlin) 23:162
    [Google Scholar]
  7. Huebner R. J. 1967; Adenovirus directed tumour and T antigens. In Perspectives in Virology Vol 5 p. 147 Ed. by Pollard M. New York and London: Academic Press;
    [Google Scholar]
  8. Hull R. N., Johnson I. S., Culbertson C. G., Reimer C. B., Wright H. F. 1965; Oncogenicity of the simian adenoviruses. Science, New York 150:1044
    [Google Scholar]
  9. Kato R. 1968; Chromosome breakage induced by a carcinogenic hydrocarbon in Chinese hamster cells and human leukocytes in vitro . Hereditas 59:120
    [Google Scholar]
  10. Kit S., Nakajima K., Dubbs D. R. 1970; Origin of thymidine kinase in adenovirus-infected human cell lines. Journal of Virology 5:446–450
    [Google Scholar]
  11. McAllister R. M., Nicolson M. O., Reed G., Kern J., Gilden R. V., Huebner R. J. 1969; Transformation of rodent cells by adenovirus 19 and other group D adenoviruses. Journal of the National Cancer Institute 43:917
    [Google Scholar]
  12. McDougall J. K. 1970; Effects of adenoviruses on the chromosomes of normal human cells and cells trisomic for an E chromosome. Nature, London 225:456
    [Google Scholar]
  13. MacKinnon E., Kalnins I. V., Stich H. F., Yohn D. S. 1966; Viruses and mammalian chromosomes. V. Comparative karyologic and immunofluorescent studies on Syrian hamster and human amnion cells infected with human adenovirus type 12. Cancer Research 26:612
    [Google Scholar]
  14. Migeon B. R., Miller C. S. 1968; Human-mouse somatic cell hybrids with single human chromosome (Group E): Link with thymidine kinase activity. Science, New York 162:1005
    [Google Scholar]
  15. Miles C. P., O’Neill F. 1966; Prominent secondary constrictions in a pseudo-diploid human cell line. Cytogenetics 5:321
    [Google Scholar]
  16. Moorhead P. S., Saksela E. 1963; Non-random chromosomal aberrations in SV40-transformed human cells. Journal of Cellular and Comparative Physiology 62:57
    [Google Scholar]
  17. Nicholls W. W., Peluse M., Goodheart C., McAllister R., Bradt C. 1968; Autoradiographic studies on nuclei and chromosomes of cultured leukocytes after infection with tritium-labelled adenovirus type 12. Virology 34:303
    [Google Scholar]
  18. Palmer C. G., Funderburk S. 1965; Secondary constrictions in human chromosomes. Cytogenetics 4:261
    [Google Scholar]
  19. Piña M., Green M. 1969; Biochemical studies on adenovirus multiplication. XIV. Macromolecule and enzyme synthesis in cells replicating oncogenic and non-oncogenic human adenovirus. Virology 38:573
    [Google Scholar]
  20. Reed L. J., Muench H. 1938; A simple method of estimating fifty per cent endpoints. American Journal of Hygiene 27:493
    [Google Scholar]
  21. Russell W. C., Valentine R. C., Pereira H. G. 1967; The effect of heat on the anatomy of the adenovirus. Journal of General Virology 1:509
    [Google Scholar]
  22. Sabin A. B. 1968; Viral carcinogenesis: Phenomena of special significance in the search for a viral etiology in human cancers. Cancer Research 28:1849
    [Google Scholar]
  23. Sarma P. S., Heubner R. J., Lane W. T. 1965; Induction of tumours in hamsters with an avian adeno-like virus (CELO). Science, New York 149:1108
    [Google Scholar]
  24. Schlesinger R. W. 1969; Adenoviruses: The nature of the virion and of controlling factors in productive or abortive infection and tumorigenesis. In Advances in Virus Research vol 14 New York and London: Academic Press;
    [Google Scholar]
  25. Shevliaghyn V. J., Karazas N. V. 1970; Transformation of human cells by polyoma and Rous sarcoma viruses mediated by inactivated Sendai virus. International Journal of Cancer 6:234
    [Google Scholar]
  26. Stich H. F., Van Hoosier G. L., Trentin J. J. 1964; Viruses and mammalian chromosomes. IV. Chromosome aberrations by human adenovirus type 12. Experimental Cell Research 34:400
    [Google Scholar]
  27. Stich H. F., Yohn D. S. 1965; Viruses and mammalian chromosomes. V. Chromosome aberrations in tumours of Syrian hamsters induced by adenovirus type 12. Journal of the National Cancer Institute 35:603
    [Google Scholar]
  28. Stich H. F., Avila L. R., Yohn D. S. 1968; Viruses and mammalian chromosomes. IX. The capacity of u.v.-impaired adenovirus type 18 to induce chromosome aberrations. Experimental Cell Research 53:44
    [Google Scholar]
  29. Todaro G. J., Aaronson S. A. 1968; Human cell strains susceptible to focus formation by human adenovirus type 12. Proceedings of the National Academy of Sciences of the United States of America 61:1272
    [Google Scholar]
  30. Weiss M. C., Green H. 1967; Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proceedings of the National Academy of Sciences of the United States of America 58:1104
    [Google Scholar]
  31. Zur Hausen H. 1967; Virus-cell genome interactions. I. Induction of specific chromosomal aberrations by adenovirus type 12 in human embryonic kidney cells. Journal of Virology 1:1174
    [Google Scholar]
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