Infection of primary human embryo kidney cells with adenovirus types 2, 7, 12, 18 and 31, at a multiplicity of infection of 2, resulted in the induction of chromosome aberrations in metaphases examined 24 hr after infection. The aberrations induced by types 2 and 7 were randomly distributed over the karyotype, but types 12 and 31, and to a lesser extent type 18, all induced non-random effects. Both type 12 and type 31 produced chromatid and isochromatid gaps and breaks at a specific site on chromosome no. 17.
EvansH. J.1967; Dose response relations from in vitro studies. In Human Radiation Cytogenetics p 20 Ed. by
EvansJ. H.Court-BrownW. M.,
McLeanA. S.
Amsterdam: North Holland Publishing Company;
FreemanA. E.,
BlackP. H.,
VanderpoolE. A.,
HenryP. H.,
AustinJ. B.,
HuebnerR. J.1967; Transformation of primary rat embryo cells by adenovirus type 2. Proceedings of the National Academy of Sciences of the United States of America 58:1205
HuangC. C.1967; Induction of a high incidence of damage to the X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses and carcinogens. Chromosoma (Berlin) 23:162
HuebnerR. J.1967; Adenovirus directed tumour and T antigens. In Perspectives in Virology Vol 5 p. 147 Ed. by
PollardM.
New York and London: Academic Press;
McAllisterR. M.,
NicolsonM. O.,
ReedG.,
KernJ.,
GildenR. V.,
HuebnerR. J.1969; Transformation of rodent cells by adenovirus 19 and other group D adenoviruses. Journal of the National Cancer Institute 43:917
MacKinnonE.,
KalninsI. V.,
StichH. F.,
YohnD. S.1966; Viruses and mammalian chromosomes. V. Comparative karyologic and immunofluorescent studies on Syrian hamster and human amnion cells infected with human adenovirus type 12. Cancer Research 26:612
MigeonB. R.,
MillerC. S.1968; Human-mouse somatic cell hybrids with single human chromosome (Group E): Link with thymidine kinase activity. Science, New York 162:1005
NichollsW. W.,
PeluseM.,
GoodheartC.,
McAllisterR.,
BradtC.1968; Autoradiographic studies on nuclei and chromosomes of cultured leukocytes after infection with tritium-labelled adenovirus type 12. Virology 34:303
PiñaM.,
GreenM.1969; Biochemical studies on adenovirus multiplication. XIV. Macromolecule and enzyme synthesis in cells replicating oncogenic and non-oncogenic human adenovirus. Virology 38:573
SchlesingerR. W.1969; Adenoviruses: The nature of the virion and of controlling factors in productive or abortive infection and tumorigenesis. In Advances in Virus Research vol 14 New York and London: Academic Press;
ShevliaghynV. J.,
KarazasN. V.1970; Transformation of human cells by polyoma and Rous sarcoma viruses mediated by inactivated Sendai virus. International Journal of Cancer 6:234
StichH. F.,
Van HoosierG. L.,
TrentinJ. J.1964; Viruses and mammalian chromosomes. IV. Chromosome aberrations by human adenovirus type 12. Experimental Cell Research 34:400
StichH. F.,
YohnD. S.1965; Viruses and mammalian chromosomes. V. Chromosome aberrations in tumours of Syrian hamsters induced by adenovirus type 12. Journal of the National Cancer Institute 35:603
StichH. F.,
AvilaL. R.,
YohnD. S.1968; Viruses and mammalian chromosomes. IX. The capacity of u.v.-impaired adenovirus type 18 to induce chromosome aberrations. Experimental Cell Research 53:44
TodaroG. J.,
AaronsonS. A.1968; Human cell strains susceptible to focus formation by human adenovirus type 12. Proceedings of the National Academy of Sciences of the United States of America 61:1272
WeissM. C.,
GreenH.1967; Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proceedings of the National Academy of Sciences of the United States of America 58:1104
Zur HausenH.1967; Virus-cell genome interactions. I. Induction of specific chromosomal aberrations by adenovirus type 12 in human embryonic kidney cells. Journal of Virology 1:1174