1887

Abstract

SUMMARY

When either actinomycin D or puromycin is added to cell cultures at the time of infection with herpes simplex virus, or 1 hr later, there is an inhibition of chromosomal damage induced by virus. On the other hand, cytosine arabinoside considerably potentiates the capacity of herpes simplex virus to induce chromosomal damage. This finding supports the view that chromosomal changes induced by virus are probably due to the action of early enzymes controlled by virus genes.

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1971-03-01
2021-10-27
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References

  1. Aula P., Nichols W. W. 1968; Lysosomes and virus induced chromosome breakage. Experimental Cell Research 51:595
    [Google Scholar]
  2. Aurelian L., Roizman B. 1965; Abortive infection of canine cells by herpes simplex virus. II. The alternative suppression of synthesis of interferon and viral constituents. Journal of Molecular Biology II:539
    [Google Scholar]
  3. Aya T., Makino S., Yamada M. 1967; Chromosome aberrations induced in cultured human leucocytes by herpes simplex virus infection. Proceedings of the Japan Academy 43:239
    [Google Scholar]
  4. Boiron M., Tanzer J., Thomas M., Hampe A. 1966; Early diffuse chromosome alterations in monkey kidney cells infected in vitro with herpes simplex virus. Nature, London 209:737
    [Google Scholar]
  5. Bose S. K., Warren J. R. 1969; Bacteriophage-induced inhibition of host functions. II. Evidence for multiple, sequential bacteriophage-induced deoxyribonucleases responsible for degradation of cellular deoxyribonucleic acid. Journal of Virology 3:549
    [Google Scholar]
  6. Brewen J. G. 1965; The induction of chromatid lesions by cytosine arabinoside in post-DNA-synthetic human leucocytes. Cytogenetics 4:28
    [Google Scholar]
  7. Brewen J. G., Christie N. T. 1967; Studies on the induction of chromosomal aberrations in human leucocytes by cytosine arabinoside. Experimental Cell Research 46:276
    [Google Scholar]
  8. Flanagan J. T. 1967; Virus-specific ribonucleic acid synthesis in KB cells infected with herpes simplex virus. Journal of Virology 1:583
    [Google Scholar]
  9. Géder L., Vaczi L., Gonczol E., Jeney E., Lehel F. 1967; ‘Early-non-virion’ antigens in herpes simplex virus infected tissue culture cells. Acta Microbiologica Academiae Scientiarum Hungaricae 13:357
    [Google Scholar]
  10. Hampar B., Ellison S. A. 1961; Chromosomal alterations induced by an animal virus. Nature, London 192:145
    [Google Scholar]
  11. Hampar B., Ellison S. A. 1963; Cellular alterations in the MCH line of Chinese hamster cells following infection with herpes simplex virus. Proceedings of the National Academy of Sciences of the United States of America 49:474
    [Google Scholar]
  12. Hay J., Koteles G. J., Keir H. M., Subak-Sharpe J. H. 1966; Herpesvirus specified ribonucleic acids. Nature, London 210:387
    [Google Scholar]
  13. Huang C. C. 1967; Induction of high incidence of damage to the X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses and carcinogens. Chromosoma 23:162
    [Google Scholar]
  14. Jungwirth C., Joklik W. K. 1965; Studies on ‘early’ enzymes in HeLa cells infected with vaccinia virus. Virology 27:80
    [Google Scholar]
  15. Kihlman B. A., Nichols W. W., Levan A. 1963; The effect of deoxyadenosine and cytosine arabinoside on the chromosomes of human leucocytes in vitro. Hereditas 50:139
    [Google Scholar]
  16. Kit S., Dubbs D. R. 1965; Properties of deoxythymidine kinase partially purified from noninfected and virus-infected mouse fibroblast cells. Virology 26:16
    [Google Scholar]
  17. Klemperer H. G., Haynes C. R., Shedden W. I. H., Watson D. H. 1967; A virus-specific thymidine kinase in BHK 21 cells infected with herpes simplex virus. Virology 31:120
    [Google Scholar]
  18. Kutter E. M., Wiberg J. S. 1968; Degradation of cytosine-containing bacterial and bacteriophage DNA after infection of Escherichia coli b with bacteriophage T 4D wild type and with mutants defective in genes 46, 47 and 56. Journal of Molecular Biology 38:395
    [Google Scholar]
  19. Levitt J., Becker Y. 1967; The effect of cytosine arabinoside on the replication of herpes simplex virus. Virology 31:129
    [Google Scholar]
  20. Mazzone H. M., Yerganian G. 1963; Gross and chromosomal cytology of virus-infected Chinese hamster cells. Experimental Cell Research 30:591
    [Google Scholar]
  21. Mcauslan B. R. 1963c; Control of induced thymidine kinase activity in poxvirus infected cell. Virology 20:162
    [Google Scholar]
  22. Mcauslan B. R. 1963b; Induction and repression of thymidine kinase in poxvirus infected HeLa cell. Virology 21:383
    [Google Scholar]
  23. Mcauslan B. R., Herde P., Pett D., Ross J. 1965; Nucleases of virus-infected animal cells. Biochemical and Biophysical Research Communications 20:586
    [Google Scholar]
  24. Morrison J. M., Keir H. M. 1966; Heat-sensitive deoxyribonuclease activity in cells infected with herpes simplex virus. Biochemical Journal 98:370
    [Google Scholar]
  25. Nowell P. C. 1964; Mitotic inhibition and chromosome damage by mitomycin in human leucocyte cultures. Experimental Cell Research 33:445
    [Google Scholar]
  26. Rapp F., Hsu T. C. 1965; Viruses and mammalian chromosomes. IV. Replication of herpes simplex virus in diploid Chinese hamster cells. Virology 25:401
    [Google Scholar]
  27. Reich F., Franklin R. M., Shatkin A. J., Tatum E. L. 1962; Action of actinomycin D on animal cells and viruses. Proceedings of the National Academy of Sciences of the United States of America 48:1238
    [Google Scholar]
  28. Roizman B., Aurelian L., Roane P. R. 1963; The multiplication of herpes simplex virus. I. The programming of viral DNA multiplication in HEp-2 cells. Virology 21:482
    [Google Scholar]
  29. Roizman B., Borman G., Kamali-Rousta M. 1965; Macromolecular synthesis in cells infected with herpes simplex virus. Nature, London 206:1374
    [Google Scholar]
  30. Rothfels K. H., Siminovitch L. 1958; An air drying technique for flattening chromosomes in mammalian cells grown in vitro. Stain Technology 33:73
    [Google Scholar]
  31. Russell W. C., Gold E., Keir H. M., Omura H., Watson D. H., Wildy P. 1964; The growth of herpes simplex virus and its nucleic acid. Virology 22:103
    [Google Scholar]
  32. Sablina O. V., Bocharov E. F. 1968; Chromosomal aberrations in the HeLa and HEp-2 tissue culture cells induced by herpes simplex virus. Genetika 4:128
    [Google Scholar]
  33. Spear P. C., Roizman B. 1968; The proteins specified by herpes simplex virus. I. Time of synthesis, transfer into nuclei, and properties of proteins made in productively infected cells. Virology 36:545
    [Google Scholar]
  34. Stich H. F., Hsu T. C., Rapp F. 1964; Viruses and mammalian chromosomes. I. Localization of chromosome aberrations after infection with herpes simplex virus. Virology 22:439
    [Google Scholar]
  35. Warren R. J., Bose S. K. 1968; Bacteriophage-induced inhibition of host functions. I. Degradation of Escherichia coli deoxyribonucleic acid after T 4 infection. Journal of Virology 2:327
    [Google Scholar]
  36. Wiberg J. S. 1966; Mutants of bacteriophage T 4 unable to cause breakdown of host DNA. Proceedings of the National Academy of Sciences of the United States of America 53:614
    [Google Scholar]
  37. Wiberg J. S. 1967; Amber mutants of bacteriophage T 4 defective in deoxycytidine diphosphatase and deoxycytidine triphosphatase. On the role of 5-hydroxylmethylcytosine in bacteriophage deoxyribonucleic acid. Journal of Biological Chemistry 242:5824
    [Google Scholar]
  38. Zur Hausen H. 1967; Induction of specific chromosomal aberrations by adenovirus type 12 in human embryonic kidney cells. Journal of Virology 1:1174
    [Google Scholar]
  39. Zur Hausen H. 1968; Association of adenovirus type 12 deoxyribonucleic acid with host cell chromosomes. Journal of Virology 2:218
    [Google Scholar]
  40. Zur Hausen H., Lanz E. 1966; Chromosomale Aberrationen bei L-Zellen nach Vaccinia-Virus-Infektion. Zeitschrift für medizinische Mikrobiologie und Immunologie 15260
    [Google Scholar]
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