RT Journal Article SR Electronic(1) A1 Pilch, D. J. F. A1 Planterose, D. N.YR 1971 T1 Effects on Friend Disease of Double-stranded RNA of Fungal Origin JF Journal of General Virology, VO 10 IS 2 SP 155 OP 162 DO https://doi.org/10.1099/0022-1317-10-2-155 PB Microbiology Society, SN 1465-2099, AB SUMMARY This paper reports the effects of treatment with double-stranded RNA of Friend disease, a virus-induced murine leukaemia. The salient feature of the disease is a progressive increase in spleen size; death normally results from rupture of the spleen. It was found that the effect of treatment with double-stranded RNA was closely related to the time of treatment relative to infection. Treatment before or in the early stages of infection increased the severity of the disease, but treatment 5 days after infection led to a profound reduction in the severity of the disease, judged by a pronounced reduction or abolition of splenomegaly. Histological examination of this reversal of splenomegaly showed reduction of the Friend cell infiltration and a return to a more normal spleen architecture. Mice in which remissions have been produced have remained free of evidence of splenomegaly for several weeks. The nature of this therapeutic effect is unknown., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-10-2-155