@article{mbs:/content/journal/jgv/10.1099/0022-1317-10-2-155, author = "Pilch, D. J. F. and Planterose, D. N.", title = "Effects on Friend Disease of Double-stranded RNA of Fungal Origin", journal= "Journal of General Virology", year = "1971", volume = "10", number = "2", pages = "155-162", doi = "https://doi.org/10.1099/0022-1317-10-2-155", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-10-2-155", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY This paper reports the effects of treatment with double-stranded RNA of Friend disease, a virus-induced murine leukaemia. The salient feature of the disease is a progressive increase in spleen size; death normally results from rupture of the spleen. It was found that the effect of treatment with double-stranded RNA was closely related to the time of treatment relative to infection. Treatment before or in the early stages of infection increased the severity of the disease, but treatment 5 days after infection led to a profound reduction in the severity of the disease, judged by a pronounced reduction or abolition of splenomegaly. Histological examination of this reversal of splenomegaly showed reduction of the Friend cell infiltration and a return to a more normal spleen architecture. Mice in which remissions have been produced have remained free of evidence of splenomegaly for several weeks. The nature of this therapeutic effect is unknown.", }