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Journal of General Virology header logo Journal of General Virology

Volume 10, Issue 2

Effects on Friend Disease of Double-stranded RNA of Fungal Origin No Access

Abstract

SUMMARY

This paper reports the effects of treatment with double-stranded RNA of Friend disease, a virus-induced murine leukaemia. The salient feature of the disease is a progressive increase in spleen size; death normally results from rupture of the spleen. It was found that the effect of treatment with double-stranded RNA was closely related to the time of treatment relative to infection. Treatment before or in the early stages of infection increased the severity of the disease, but treatment 5 days after infection led to a profound reduction in the severity of the disease, judged by a pronounced reduction or abolition of splenomegaly. Histological examination of this reversal of splenomegaly showed reduction of the Friend cell infiltration and a return to a more normal spleen architecture. Mice in which remissions have been produced have remained free of evidence of splenomegaly for several weeks. The nature of this therapeutic effect is unknown.

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© Journal of General Virology 1971
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1971-02-01
2025-05-12
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/content/journal/jgv/10.1099/0022-1317-10-2-155
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Effects on Friend Disease of Double-stranded RNA of Fungal Origin
J. Gen. Virol. 10, 155 (1971); https://doi.org/10.1099/0022-1317-10-2-155
/content/journal/jgv/10.1099/0022-1317-10-2-155
/content/journal/jgv/10.1099/0022-1317-10-2-155
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