1887

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Volume 10, Issue 2

Effects on Friend Disease of Double-stranded RNA of Fungal Origin Free

Abstract

SUMMARY

This paper reports the effects of treatment with double-stranded RNA of Friend disease, a virus-induced murine leukaemia. The salient feature of the disease is a progressive increase in spleen size; death normally results from rupture of the spleen. It was found that the effect of treatment with double-stranded RNA was closely related to the time of treatment relative to infection. Treatment before or in the early stages of infection increased the severity of the disease, but treatment 5 days after infection led to a profound reduction in the severity of the disease, judged by a pronounced reduction or abolition of splenomegaly. Histological examination of this reversal of splenomegaly showed reduction of the Friend cell infiltration and a return to a more normal spleen architecture. Mice in which remissions have been produced have remained free of evidence of splenomegaly for several weeks. The nature of this therapeutic effect is unknown.

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  • Published Online:
© Journal of General Virology 1971
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1971-02-01
2023-05-29
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References

  1. Banks G. T., Buck K. W., Chain E. B., Himmelweit F., Marks J. E., Tyler J. M., Hollings M., Last F. T., Stone O. M. 1968; Viruses in fungi and interferon stimulation. Nature, London 218:542
     [Google Scholar]
  2. Bart R. S., Kopf A. W. 1969; Inhibition of the growth of murine malignant melanoma with synthetic double-stranded ribonucleic acid. Nature, London 224:372
     [Google Scholar]
  3. Fontaine-Brouty-Boyé D., Gresser I., Macieira-Coelho A., Rosenfeld C., Thomas M. 1969; Inhibition in vitro de la multiplication des cellules leucémiques murines L 1210 par des préparations d’interféron. Compte rendu hebdomadaire des séances de VAcadémie des Sciences, Paris 269:406
     [Google Scholar]
  4. Gresser I., Bourali C. 1969; Exogenous interferon and inducers of interferon in the treatment of Balb/C Mice inoculated with RC19 tumour cells. Nature, London 223:844
     [Google Scholar]
  5. Gresser I., Falcoff R., Fontaine-Brouty-Boyé D., Zajdela F., Coppey J., Falcoff E. 1967; Interferon and murine leukemia. IV. Further studies on the efficacy of interferon preparations administered after inoculation of Friend virus. Proceedings of the Society for Experimental Biology and Medicine 126: (3) 791
     [Google Scholar]
  6. Hilleman M. R. 1970; Prospects for the use of double-stranded ribonucleic acid (Poly I: C) inducers in Man. Journal of Infectious Diseases 121:196
     [Google Scholar]
  7. Hirsch M. S., Murphy F. A. 1968; Effects of anti-lymphoid sera on viral infections. Lancet (7558) ii:37
     [Google Scholar]
  8. Kleinschmidt W. J., Ellis L. F., Van Frank R. M., Murphy E. B. 1968; Interferon stimulation by a doublestranded RNA of a mycophage in Statolon preparations. Nature, London 220:167
     [Google Scholar]
  9. Larson V. M., Clark W. R., Dagle G. E., Hilleman N. R. 1969a; Influence of synthetic double-stranded ribonucleic acid, Poly I: C, on Friend leukemia in mice. Proceedings of the Society for Experimental Biology and Medicine 132:602
     [Google Scholar]
  10. Larson V. M., Clark W. R., Hilleman M. R. 1969b; Influence of synthetic (Poly I: C) and viral doublestranded ribonucleic acids on adenovirus 12 oncogenesis in hamsters. Proceedings of the Society for Experimental Biology and Medicine 131:1002
     [Google Scholar]
  11. Levy H. B., Law W. L., Rabson A. S. 1969; Inhibition of tumor growth by Polyinosinic-polycytidylic Acid. Proceedings of the National Academy of Sciences of the United States of America 62:357
     [Google Scholar]
  12. Nemes M. M., Tytell A. A., Lampson G. P., Field A. K., Hilleman M. R. 1969; Inducers of interferon and host resistance. VII. Antiviral efficacy of double-stranded RNA of natural origin. Proceedings of the Society for Experimental Biology and Medicine 132:784
     [Google Scholar]
  13. Planterose D. N., Birch P. J., Pilch D. J. F., Sharpe T. J. 1970; Antiviral activity of the double-stranded RNA and virus-like particles from. Penicillium stoloniferum, Nature, London 227:504
     [Google Scholar]
  14. Wheelock E. F. 1967; Effect of Statolon on Friend virus leukemia in mice. Proceedings of the Society for Experimental Biology and Medicine 124:855
     [Google Scholar]
  15. Wheelock E. F., Caroline N. L., Moore R. D. 1969; Suppression of established Friend virus leukemia by Statolon. Journal of Virology 41
     [Google Scholar]
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Effects on Friend Disease of Double-stranded RNA of Fungal Origin
J. Gen. Virol. 10, 155 (1971); https://doi.org/10.1099/0022-1317-10-2-155
/content/journal/jgv/10.1099/0022-1317-10-2-155
/content/journal/jgv/10.1099/0022-1317-10-2-155
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