1887

Abstract

Summary

Cells infected with Newcastle disease virus contained significant amounts of base-paired RNA. Base pairing in this RNA was suggested by its resistance to ribonuclease and by the sharp thermal transition from ribonuclease resistance to sensitivity at 83° in 0.01 -NaCl. The base-paired RNA sediments heterogeneously with a peak at 35 .

Preferential labelling of the base-paired RNA after short periods of incubation with [H]uridine suggests that it may serve as an intermediate in the synthesis of single-stranded virus-specific RNA. The kinetics of [H]uridine incorporation into the various species of virus-specific RNA are discussed.

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/content/journal/jgv/10.1099/0022-1317-10-2-139
1971-02-01
2019-10-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-10-2-139
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