1887

Abstract

SUMMARY

Semliki Forest virus, inactivated by incubation at 37°, induced considerably more interferon than did the live virus. Infection by live virus produced an earlier termination of interferon synthesis (at 8 hr) which correlated with a profound inhibition of cellular RNA synthesis. Heat-inactivated Semliki Forest virus did not inhibit cellular RNA synthesis until much later and permitted continuation of interferon synthesis for an additional 4 hr, thereby increasing the yield of interferon by about four- to sixfold.

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/content/journal/jgv/10.1099/0022-1317-10-2-117
1971-02-01
2022-01-22
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References

  1. Aurelian L., Roizman B. 1965; Abortive infection of canine cells by Herpes simplex virus. II. Alternate suppression of synthesis of interferon and viral constituents. Journal of Molecular Biology 11:539
    [Google Scholar]
  2. Burke D. C. 1966; The Production of Interferons by Viruses: Mechanisms. In Interferons p 55 Ed. by Finter N. B. Philadelphia: W. B. Saunders Co;
    [Google Scholar]
  3. Burke D. C., Isaacs A. 1958; Some factors affecting the production of interferon. British Journal of Experimental Pathology 39:452
    [Google Scholar]
  4. Gandhi S. S., Burke D. C. 1970; Interferon production by myxoviruses in chick embryo cells. Journal of General Virology 6:95
    [Google Scholar]
  5. Gifford G. E., Heller E. 1963; Effect of actinomycin D on interferon production by ‘active’ and ‘inactive’ chikungunya virus in chick cells. Nature, London 200:50
    [Google Scholar]
  6. Goorha R. M., Gifford G. E. 1970; Interferon induction by heat inactivated Semliki Forest virus. Proceedings of the Society for Experimental Biology and Medicine 134:1142
    [Google Scholar]
  7. Heller E. 1963; Enhancement of Chikungunya virus replication and inhibition of interferon production by actinomycin D. Virology 21:652
    [Google Scholar]
  8. Henderson J. R., Taylor R. M. 1961; Studies on mechanisms of Arthropod borne virus interference in tissue culture. Virology 13:477
    [Google Scholar]
  9. Ho M. 1964; Identification and ‘induction’ of interferon. Bacteriological Reviews 28:367
    [Google Scholar]
  10. Ho M., Enders J. F. 1959; Further studies on an inhibitor of viral activity appearing in infected cell cultures and its role in chronic viral infections. Virology 9:446
    [Google Scholar]
  11. Ho M., Breinig M. K. 1962; Conditions for the production of an interferon appearing in chick cell cultures infected with Sindbis virus. Journal of Immunology 89:117
    [Google Scholar]
  12. Isaacs A., Lindenmann J. 1957; Virus interference. I. The interferon. Proceedings of the Royal Society B, 147:258
    [Google Scholar]
  13. Lindenmann J., Gifford G. E. 1963a; Studies on vaccinia virus plaque formation and its inhibition by interferon. I. Dynamics of plaque formation by vaccinia virus. Virology 19:283
    [Google Scholar]
  14. Lindenmann J., Gifford G. E. 1963b; Studies on vaccinia virus plaque formation and its inhibition by interferon. III. A simplified plaque inhibition assay of interferon. Virology 19:302
    [Google Scholar]
  15. Lockart R. Z. Jun 1963; Production of an interferon by L cells infected with Western Equine Encephalomyelitis virus. Journal of Bacteriology 85:556
    [Google Scholar]
  16. Wagner R. R. 1964; Inhibition of interferon biosynthesis by actinomycin D. Nature, London 204:49
    [Google Scholar]
  17. Wagner R. R., Huang A. S. 1965; Reversible inhibition of interferon synthesis by puromycin: Evidence for an interferon specific messenger RNA. Proceedings of the National Academy of Sciences of the United States of America 54:1112
    [Google Scholar]
  18. Wagner R. R., Huang A. S. 1966; Inhibition of RNA and interferon synthesis in Kreb-2 cells infected with vesicular stomatitis virus. Virology 28:1
    [Google Scholar]
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