1887

Abstract

Summary

Semliki Forest virus, inactivated by incubation at 37°, induced considerably more interferon than did the live virus. Infection by live virus produced an earlier termination of interferon synthesis (at 8 hr) which correlated with a profound inhibition of cellular RNA synthesis. Heat-inactivated Semliki Forest virus did not inhibit cellular RNA synthesis until much later and permitted continuation of interferon synthesis for an additional 4 hr, thereby increasing the yield of interferon by about four- to sixfold.

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/content/journal/jgv/10.1099/0022-1317-10-2-117
1971-02-01
2019-10-15
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-10-2-117
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