RT Journal Article SR Electronic(1) A1 Walters, Shan A1 Burke, D. C. A1 Skehel, J. J.YR 1967 T1 Interferon Production and RNA Inhibitors JF Journal of General Virology, VO 1 IS 3 SP 349 OP 362 DO https://doi.org/10.1099/0022-1317-1-3-349 PB Microbiology Society, SN 1465-2099, AB Summary Investigation of the effects of 4,5,6-trichloro-1β-d-ribofuranosyl benzimidazole and 2-mercapto-1-(β-4-pyridethyl) benzimidazole on cellular RNA synthesis and virus multiplication showed that both compounds, like actino-mycin, preferentially inhibited DNA-directed RNA synthesis. All three compounds inhibited interferon production initiated by several different viruses, and actinomycin inhibited interferon production almost as rapidly as it inhibited DNA-directed RNA synthesis. It was concluded that the compounds inhibited interferon production because of their primary action on DNA-directed RNA synthesis. Interferon production initiated by Chikungunya virus and ultraviolet-inactivated Newcastle disease virus was unaffected by addition of the inhibitors after interferon production had begun, while interferon production initiated by ultraviolet-inactivated influenza virus remained partially susceptible to the effect of the inhibitors., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-1-3-349