The infective process of a filamentous bacteriophage was studied in the electron microscope using thin sections of cells of infected at a high multiplicity. Marked intracellular changes beginning after about 20 min. consisted of multiple layer membraneous structures and mesosomes formed by the invagination of the cell wall and the protoplasmic membrane. At the same time many particles were extruded and appeared in transverse section as small circles with a black dot, believed to be the nucleic acid core. It was difficult to see particles within the cell or being extruded from it, but some evidence suggested that bacteriophage synthesis was occurring near the cell wall. There was no abrupt lysis; the cell contents slowly leaked out leaving an intact cell envelope.


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