The antiviral effects of three substituted benzimidazoles, 4,5,6,trichloro-1-β--ribofuranosyl benzimidazole, 2-mercapto-1-(β-4-pyridethyl) benzimidazole and 2-(α-hydroxybenzyl) benzimidazone, have been investigated and compared with their effects on the RNA metabolism of the host cells.

4,5,6,trichloro-1-β--ribofuranosyl benzimidazole and 2-mercapto-1-(β-4-pyridethyl) benzimidazole inhibit the growth of influenza A and parainfluenza 1 in calf kidney cells, and vaccinia in L cells, but they also reduce the synthesis of cellular RNA proportionately. They inhibit the growth of EMC in L cells, but only at concentrations at which host cell RNA synthesis is very much reduced. Their action is therefore not specific to a virus induced process.

In contrast, 2-(α-hydroxybenzyl) benzimidazole suppresses the growth of encephalomyocarditis virus in L cells at concentrations which have little effect on host cell RNA synthesis.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error