1887

Abstract

Summary

The antiviral effects of three substituted benzimidazoles, 4,5,6,trichloro- l---ribofuranosyl benzimidazole, 2-mercapto-1 -(-4-pyridethyl) benzimidazole and 2-(-hydroxybenzyl) benzimidazone, have been investigated and compared with their effects on the RNA metabolism of the host cells.

4,5,6,trichloro-l---ribofuranosyl benzimidazole and 2-mercapto-l-(-4- pyridethyl) benzimidazole inhibit the growth of influenza A and parainfluenza 1 in calf kidney cells, and vaccinia in L cells, but they also reduce the synthesis of cellular RNA proportionately. They inhibit the growth of EMC in L cells, but only at concentrations at which host cell RNA synthesis is very much reduced. Their action is therefore not specific to a virus induced process.

In contrast, 2-(-hydroxybenzyl) benzimidazole suppresses the growth of encephalomyocarditis virus in L cells at concentrations which have little effect on host cell RNA synthesis.

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/content/journal/jgv/10.1099/0022-1317-1-1-89
1967-01-01
2021-10-19
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