1887

Abstract

The taxonomic position of members of the complex has been the subject of intensive investigation and, in some aspects confusion, in recent years as a result of varying approaches to genetic data interpretation. Currently, the former species and are grouped together as subsp. . They differ greatly, however, as the former has a functional (41) gene that confers inducible resistance to macrolides, the primary therapeutic antimicrobials for , while in the former the (41) gene is non-functional. Furthermore, previous whole genome studies of the group support the separation of and . To shed further light on the population structure of , 43 strains and three genomes retrieved from GenBank were subjected to pairwise comparisons using three computational approaches: verage ucleotide dentity, enome to enome istance and single nucleotide polymorphism analysis. The three methods produced overlapping results, each demonstrating three clusters of strains corresponding to the same number of taxonomic entities. The distances were insufficient to warrant distinction at the species level, but met the criteria for differentiation at the subspecies level. Based on prior (41)-related phenotypic data and current genomic data, we conclude that the species encompasses, in adjunct to the presently recognized subspecies subsp. and subsp. , a third subspecies for which we suggest the name subsp. comb. nov. (type strain CCUG 48898=CIP 108297=DSM 45103=KCTC 19086).

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2016-11-01
2020-01-23
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