%0 Journal Article %A Shafiee, Ahmad %A Amini, Massoud %A Emamirad, Hassan %A Abadi, Amin Talebi Bezmin %T Recombination and phenotype evolution dynamics of Helicobacter pylori in colonized hosts %D 2016 %J International Journal of Systematic and Evolutionary Microbiology, %V 66 %N 7 %P 2471-2477 %@ 1466-5034 %R https://doi.org/10.1099/ijsem.0.001072 %K evolution %K Lewis antigen %K mutation %K Helicobacter pylori %K stabilization %K selection %K recombination %I Microbiology Society, %X The ample genetic diversity and variability of Helicobater pylori, and therefore its phenotypic evolution, relate not only to frequent mutation and selection but also to intra-specific recombination. Webb and Blaser applied a mathematical model to distinguish the role of selection and mutation for Lewis antigen phenotype evolution during long-term gastric colonization in infected animal hosts (mice and gerbils). To investigate the role of recombination in Lewis antigen phenotype evolution, we have developed a prior population dynamic by adding recombination term to the model. We simulate and interpret the new model simulation's results with a comparative analysis of biological aspects. The main conclusions are as follows: (i) the models and consequently the hosts with higher recombination rate require a longer time for stabilization; and (ii) recombination and mutation have opposite effects on the size of H. pylori populations with phenotypes in the range of the most-fit ones (i.e. those that have a selective advantage) due to natural selection, although both can increase phenotypic diversity. %U https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.001072