1887

Abstract

strain 45H, isolated in 1960 during a mutagenesis programme on the industrial streptomycin producer 52-1, encodes an extracellular, pleiotropic autoregulatory signalling protein, factor C, which stimulates sporulation of 52-1 in submerged culture. The gene, which codes for factor C, is present in very few streptomycetes and is not present in 52-1. Based on 16S rRNA gene sequencing and other molecular data, 45H, the factor C producer, is here shown to be related to the original laboratory strain of , which was being studied in the same laboratory in 1960, and to . Southern blotting revealed that three out of four independently isolated strains of possess . Both the original strain of and 45H are therefore identified as members of the species , and we propose that 45H should be renamed 45H.

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2008-04-01
2019-12-08
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