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Abstract

Overlapping genes have been proposed as a means of achieving genome reduction by compressing the maximum amount of information in limited sequence space. In this report, comparative analyses of the overlapping genes of genomes of nine bacteria with different lifestyles were performed. The results clearly suggest that overlapping genes may be a result of evolutionary pressure to minimize genome size. The genomes of two closely related obligatory intracellular parasites – and – were investigated further. Detailed analyses of these two genomes revealed that mutations at the ends of coding regions and elimination of intergenic DNA are the main forces that determine overlapping of genes.

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2005-05-01
2020-01-18
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Supplements

vol. , part 3, pp. 1205–1209

The overlapping gene pairs of the rickettsial species have been classified into four categories. The gene identification number, the gene name, the direction of overlap and the number of overlapping nucleotides have been tabulated for each category and are available to download. [PDF](144KB)



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