The structural divergence of catalase derived from different mycobacteria has previously been studied in terms of immunological distances as determined by titration with antiserum against catalase extracted from . This study has been extended by addition of a second reference antiserum: One raised against catalase from The two systems show a high reciprocality of immunological distance against one another. The catalase from is serologically very similar to that of , and the enzyme from is very similar to that of . Catalase extracted from BCG, a pathovar of , appears to exhibit structural modification which diverges from the parent and converges on . Two classes of catalase have been separated from : One is nonreactive with either reference antiserum, and the other exhibits immunological distances that suggest that is in a position between and .


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