One hundred twenty-five strains of mainly fast-growing mycobacteria and representatives of related taxa were screened for susceptibility to 50, 100, and 200 μg of isoniazid per ml. Over 80% of the mycobacterial strains were susceptible to 200 μg of isoniazid per ml, with the resistant ones restricted to the species , and With a single exception, representatives of the taxa , and were resistant to the concentrations of isoniazid tested. The susceptibility of most fast-growing mycobacteria to high concentrations of isoniazid seems to provide the basis of a useful test to distinguish the majority of these organisms from related actinomycete and coryneform bacteria.


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