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Abstract

Otitis media is a perforation of the middle ear caused by pathogenic microorganisms which leads to hearing impairment. There is a need for alternative methods to the use of antibiotics in combatting the impairment owing to the challenge of antibiotics resistance. This study is aimed at identifying and determining susceptibility pattern of bacterial isolates from otitis media patients to cigarette capsule and Nicotiana tabacum extract. Forty eight samples were collected from a tertiary hospital in Abeokuta Ogun state- 28 (58.33%) from males and 20 (41.67%) from females with highest occurrence in children below the age of 5 (60%).Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniaeandProteus mirabiliswere isolated. The two different products of cigarette capsules used showed significant (P < 0.05) zones of inhibition onPseudomonas aeruginosa and Streptococcus pneumonia respectively. Results also revealed that Nicotiana tabacum extract had significant effect (P < 0.05) onKlebsiella pneumonia, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureusandStreptococcus pneumonia at 0.5 mg, 1.0mg and 2.0mg. This study shows the antibacterial activity of Nicotiana tabacum methanolic leaf extract making it a promising raw material in the production of new classes of antibiotics against otitis media infection.

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/content/journal/acmi/10.1099/acmi.fis2019.po0202
2020-02-28
2020-06-04
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http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.fis2019.po0202
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