infection (CDI) adversely affects patient outcomes. CDI 30-day mortality is 15.2% nationally with some regional variation, but data on recurrence is limited. We assessed outcomes of CDI, in particular recurrence and mortality at Addenbrooke’s Hospital.


We performed a retrospective analysis of all patients who developed CDI between April 2017 and March 2018. All-cause mortality was assessed at 30 days and 1 year. Recurrence was defined as recurrence of symptoms withC. difficiletoxin positive stool or initiationof treatment within 1-year after onset of first/previous episode. First-line therapy was metronidazole or vancomycin according to severity.

Clinical data was collected using a standardised proforma. Risk of recurrence was calculated using Cox’s Hazard method in R.


143 cases of CDI in 103 patients were identified. The median age was 70 years (range 2-98). Recurrence rate was 24.6% at 12-weeks and 30.3% at 1-year. 30-day and 1-year mortality was 14.4% and 39.8%, respectively. Recurrences had longer mean length of stay compared to 1stepisodes (40.3 vs. 18 days, respectively, p<0.05). On univariate analysis, no factors predicted recurrence; acute kidney injury, C-reactive protein, toxic megacolon, Charlson comorbidity score and age predicted mortality.


CDI carries a significant mortality and recurrence rate placing a large burden on hospital resources. The majority of recurrences occur within 12 weeks of 1stepisode, and patients’ risk could not be accurately defined in this sample. Newer therapies with reported lower recurrence rates should be considered as 1stline therapy within our Trust.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.

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