In-Vitro Antibacterial Therapy of Ficus exasperata, Securinega virosa and Tamarindus indica Leaf Extract on Bacterial Isolate from Otitis Media effusion

Antibiotics resistance which is a global health challenge is no longer a future threat but a present challenge to all facet of clinical settings. Thus, treatment of Otitis media effusion in this regards is a major concern.

The aim of this study was to determine the efficacy of three medicinal plant extract in the treatment of Otitis media as an alternative therapy.

The antibacterial effect of absolute methanol leaf extract of Ficus exasperate, Securinega virosa,and Tamarindus indica on organisms isolated from otitis media effusion was determined using agar well diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was also determined using the double fold dilution technique. Treatment means were compared with Duncan’s New Multiple Range Test at 5% level of significance using Statistical Analysis System

Bacteria isolated include Staphylococcus aureus 19(39.58%), Klebsiella pneumonia 15(31.25%), Pseudomonas aeruginosa 10(20.83%), Proteus mirabilis3(6.25%) and Streptococcus pneumoniae 1(2.08%). At 1.0mg/ml concentration, At 1.0 mg/ml concentration, Tamarindus indicainhibited all the isolates; For Ficus exasperate,the MIC was 0.39 mg/ml and MBC was 0.78 mg/ml against Pseudomonas aeruginosa; Securinega virosa MIC was 0.78mg/ml and MCB 1.56mg/ml against Staphylococcus aureus, Pseudomonas aeruginosaand Klebsiella pneumoniae. Tamrindus indica lowest MIC was 0.39 mg/ml and MBC of 1.56 mg/ml against streptococcus pneumoniae. The antimicrobial activity of the three extracts shows significant (P<0.05) inhibition for the organisms.

This study showed the potentials of the aforementioned extracts as treatment options for cases of OME.