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Abstract

is an emerging, multidrug resistant fungal pathogen that has become a public health threat worldwide. spreads easily among patients within and between hospitals, and the incidence of infections has increased substantially in the last decade. Multiple outbreaks have been reported worldwide including India, USA and United Kingdom. Infections and outbreaks caused by have also been reported in the Middle East region including Kuwait, Oman, Saudi Arabia, and Qatar; however, the origin of these isolates is largely unknown. This study uses whole genome sequencing (WGS) data to determine the epidemiology and the drug resistance mutations from in Qatar. Forty samples isolated from the patients and the hospital environment were sequenced by Illumina Nextseq. Core genome SNPs revealed that all isolates belonged to the Indian lineage, which could be originated from the expatriate labour from South Asia. The genetic variability among the isolates was low but comprised of more than one genetic cluster. The environmental isolates were identical to the clinical isolates, and the isolates from patients of different hospitals/outbreaks clustered together, suggesting the transmission of could be linked to infected/colonized patients and the hospital environment. Mutations associated with azole and echinocandin resistance were discussed.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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/content/journal/acmi/10.1099/acmi.cc2021.po0171
2021-12-17
2022-01-28
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http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.cc2021.po0171
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