The search for alternative, potent, cost-effective treatment of ailments caused by resistant microorganisms and the role of plants and their products as essential sources of medicinal agents is receiving increasing attention. Several of these natural products are reported to have capacity to produce natural compounds of high structural diversity that serve as defense agents against invading microorganisms. Cnidoscolus aconitifolius also known as tree spinach is an indigenous tropical tree that has gained lot of importance in its nutritive value and traditional use. This study evaluates the possible effect of Cnidoscolus aconitifolius leaf extract alone, extract/honey combination on Staphylococcus epidermidis clinical isolate. Phytochemical analysis and antimicrobial efficacy of the extract were performed using standard methods. The results of phytochemical analysis reveal the presence of carbohydrate, tannins, alkaloids, steroids, flavonoids, anthraquinone, saponins and carotenoids. Antimicrobial activities showed inhibition zone values of 8.0±0.1 mm for aqueous extract alone, 9.0±0.1 mm for aqueous extract/honey combination. The finding suggests that C. aconitifolius might be a good source of compounds that can be used to inhibit the growth of Staphylococcus epidermidis pathogen and further supports its popular and wide traditional applications in the treatment of various illnesses. Hence the need for further research to exploit the full potential of C. aconitifolius tree in order to influence their extensive consumption, storage, improvement and production.

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