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Volume 8, Issue 1

The putative LysR-type transcriptional regulator YybE and its connection to chromosome replication and segregation Open Access

Abstract

Duplication and segregation of genetic material are vital for cell proliferation. Deletion of DNA replication regulators, such as YabA and ParA, leads to over-initiation of DNA replication. However, the viability of the double mutant suggests additional regulatory mechanisms. Using a transposon mutagenesis library, was identified as a potential candidate. Bioinformatic analysis of suggests that it encodes a putative LysR-type transcriptional regulator (LTTR). LTTRs are established regulators of metabolic processes, leading to the hypothesis that YybE might link metabolic processes to DNA replication. However, under the tested conditions, deletion of did not result in detectable changes to DNA replication frequency, origin segregation or chromosome morphology.

  • Received:
  • Accepted:
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Keyword(s): Bacillus subtilis , chromosome morphology , DNA replication initiation , LysR-transcriptional regulator , YabA and YybE
Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/S00257X/1)
    • Principal Award Recipient: NotApplicable
© 2026 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2026-01-07
2026-01-23

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The Bacillus subtilis putative LysR-type transcriptional regulator YybE and its connection to chromosome replication and segregation
Access Microbiology 8, 001000.v4 (2026); https://doi.org/10.1099/acmi.0.001000.v4
/content/journal/acmi/10.1099/acmi.0.001000.v4
/content/journal/acmi/10.1099/acmi.0.001000.v4
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