1887

Abstract

KSHV viral FLICE inhibitory protein (vFLIP) is a potent activator of NF-κB signalling and an inhibitor of apoptosis and autophagy. Inhibition of vFLIP function and NF-κB signalling promotes lytic reactivation. Here we provide evidence for a novel function of vFLIP through inhibition of the deubiquitinating (DUB) activity of the negative regulator, A20. We demonstrate direct interaction of vFLIP with Itch and A20 and provide evidence for subsequent loss of A20 DUB activity. Our results provide further insight into the function of vFLIP in the regulation of NF-κB signalling.

Funding
This study was supported by the:
  • National Institute of Allergy and Infectious Diseases (Award AI157907)
    • Principle Award Recipient: ELANAEhrlich
  • National Institute of General Medical Sciences (Award GM118011)
    • Principle Award Recipient: ELANAEhrlich
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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/content/journal/acmi/10.1099/acmi.0.000625.v4
2024-05-09
2024-05-23
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