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Abstract

This study was conducted to assess factors associated with cutaneous colonization of Mucormycetes in diabetic and non-diabetic individuals. A total of 800 swab samples from 200 participants including 100 diabetics and 100 non-diabetics were collected from four different body sites: (1) the forehead, (2) nasal cavity, (3) hands and (4) feet. Fungal isolation, fungal identification and antibiotic sensitivity tests were performed on the isolates. Overall, 12.0 % of the participants showed Mucormycetes colonization while the commonest fungal isolates were Species (Spp.). followed by spp. Diabetics had a 11 times higher odds of colonization compared to non-diabetics. The majority of the isolates were resistant to itraconazole; however, all isolates were sensitive to amphotericin B. A significant association was observed between profession and Mucormycetes (=0.03) with significantly higher colonization in retired people compared to business people. Higher odds of colonization were demonstrated among older ages, lower class status and individuals with prolonged contact time with soil.

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/content/journal/acmi/10.1099/acmi.0.000495.v4
2023-09-06
2026-02-11

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References

  1. Saud B, Chand K, Amatya N, Paudel G, Adhikari S et al. Factors associated with cutaneous colonization of mucormycetes in diabetic and non-diabetic individuals. Figshare 2023 [View Article]
    [Google Scholar]
  2. Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005; 18:556–569 [View Article] [PubMed]
    [Google Scholar]
  3. [Google Scholar]
  4. Prakash H, Chakrabarti A. Epidemiology of mucormycosis in India. Microorganisms 2021; 9:1–12 [View Article] [PubMed]
    [Google Scholar]
  5. Sharma A, Goel A. Mucormycosis: risk factors, diagnosis, treatments, and challenges during COVID-19 pandemic. Folia Microbiol 2022; 67:363–387 [View Article] [PubMed]
    [Google Scholar]
  6. Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005; 41:634–653 [View Article] [PubMed]
    [Google Scholar]
  7. Kandregula S, Behura A, Behera CR, Pattnaik D, Mishra A et al. A clinical significance of fungal infections in diabetic foot ulcers. Cureus 2022; 14:e26872 [View Article] [PubMed]
    [Google Scholar]
  8. Theophilus Kachi U, Victoria Nneka A, Uche E. Assessment of systemic fungal infections among diabetic patients in Enugu, Nigeria. J Infect Dis Epidemiol 2018; 4: [View Article]
    [Google Scholar]
  9. Uprety S, Lamichhane B. Backgrounder series: diabetes. Herd Res Soc Dev Forum 20161–5
    [Google Scholar]
  10. Khanna M, Challa S, Kabeil AS, Inyang B, Gondal FJ et al. Risk of mucormycosis in diabetes mellitus: a systematic review. Cureus 2021; 13:e18827 [View Article] [PubMed]
    [Google Scholar]
  11. Clinical and Laboratory Standards Institute M44-A2 Method for Antifungal Disk Diffusion Susceptibility Testing of Yeasts. 2nd edn Approved Guideline; 2009
    [Google Scholar]
  12. Stemler J, Hamed K, Salmanton-García J, Rezaei-Matehkolaei A, Gräfe SK et al. Mucormycosis in the middle east and North Africa: analysis of the FungiScope® registry and cases from the literature. Mycoses 2020; 63:1060–1068 [View Article] [PubMed]
    [Google Scholar]
  13. Afroze SN, Korlepara R, Rao GV, Madala J. Mucormycosis in a diabetic patient: a case report with an insight into its pathophysiology. Contemp Clin Dent 2017; 8:662–666 [View Article] [PubMed]
    [Google Scholar]
  14. Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A et al. The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. Lancet Microbe 2022; 3:e543–e552 [View Article] [PubMed]
    [Google Scholar]
  15. World Health Organisation Diabetes. n.d https://www.who.int/health-topics/diabetes#tab=tab_1
  16. Flood D, Seiglie JA, Dunn M, Tschida S, Theilmann M et al. The state of diabetes treatment coverage in 55 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data in 680 102 adults. Lancet Healthy Longev 2021; 2:e340–e351 [View Article] [PubMed]
    [Google Scholar]
  17. Saud B, Bajgain P, Paudel G, Shrestha V, Bajracharya D et al. Fungal Infection among diabetic and nondiabetic individuals in Nepal. Interdiscip Perspect Infect Dis 2020; 2020:7949868 [View Article] [PubMed]
    [Google Scholar]
  18. Langford S, Trubiano JA, Saxon S, Spelman D, Morrissey CO. Mucormycete infection or colonisation: experience of an Australian tertiary referral centre. Mycoses 2016; 59:291–295 [View Article] [PubMed]
    [Google Scholar]
  19. Prakash H, Ghosh AK, Rudramurthy SM, Singh P, Xess I et al. A prospective multicenter study on mucormycosis in India: epidemiology, diagnosis, and treatment. Med Mycol 2019; 57:395–402 [View Article] [PubMed]
    [Google Scholar]
  20. García-Carnero LC, Mora-Montes HM. Mucormycosis and COVID-19-associated mucormycosis: insights of a deadly but neglected mycosis. J Fungi 2022; 8:445 [View Article] [PubMed]
    [Google Scholar]
  21. Lawton G. You’re only as young as your immune system. New Sci 2020; 245:44–48 [View Article] [PubMed]
    [Google Scholar]
  22. Gong Y, Li C, Wang C, Li J, Ding M et al. Epidemiology and mortality-associated factors of invasive fungal disease in elderly patients: a 20-year retrospective study from Southern China. Infect Drug Resist 2020; 13:711–723 [View Article] [PubMed]
    [Google Scholar]
  23. Chen L, Peng W, Lan G, Long G, Yang H et al. The application of metagenomic next-generation sequencing in patients with infection or colonization caused by Lichtheimia species. Front Cell Infect Microbiol 2023; 13:1103626 [View Article] [PubMed]
    [Google Scholar]
  24. Olmos JM, Hernández JL, Pariente E, Martínez J, Valero C et al. Trabecular bone score and bone quantitative ultrasound in Spanish postmenopausal women. The Camargo cohort study. Maturitas 2020; 132:24–29 [View Article] [PubMed]
    [Google Scholar]
  25. Caetano LA, Faria T, Springer J, Loeffler J, Viegas C. Antifungal-resistant Mucorales in different indoor environments. Mycology 2019; 10:75–83 [View Article] [PubMed]
    [Google Scholar]
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