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Volume 5, Issue 6

Characterization of three genomes from Oklahoma, USA Open Access

Abstract

, the causative agent for tularaemia, is a Tier 1 select agent, and a pan-species pathogen of global significance due to its zoonotic potential. Consistent genome characterization of the pathogen is essential to identify novel genes, virulence factors, antimicrobial resistance genes, for studying phylogenetics and other features of interest. This study was conducted to understand the genetic variations among genomes of isolated from two felines and one human source. Pan-genome analysis revealed that 97.7 % of genes were part of the core genome. All three isolates were assigned to sequence type A based on single nucleotide polymorphisms (SNPs) in . Most of the virulence genes were part of the core genome. An antibiotic resistance gene coding for class A beta-lactamase was detected in all three isolates. Phylogenetic analysis showed that these isolates clustered with other isolates reported from Central and South-Central USA. Assessment of large sets of the genome sequences is essential in understanding pathogen dynamics, geographical distribution and potential zoonotic implications.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): F. tularensis , genome characterization , Oklahoma (USA) , pathogen characterization and tularaemia
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-06-14
2025-01-20
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Characterization of three Francisella tularensis genomes from Oklahoma, USA
Access Microbiology 5, 000451 (2023); https://doi.org/10.1099/acmi.0.000451
/content/journal/acmi/10.1099/acmi.0.000451
/content/journal/acmi/10.1099/acmi.0.000451
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