1887

Abstract

complex (ABC) infections are commonly polymicrobial. Examining which pathogens are most commonly co-isolated with ABC is an important first step for assessing disease potential due to pathogen-pathogen interactions.

Based on a systematic search of PubMed, Scopus and CENTRAL, we estimated percent proportions of co-isolates in polymicrobial pulmonary and bloodstream ABC infections using random-effects meta-analysis.

Twenty-eight eligible studies were analysed reporting 575 polymicrobial bloodstream and 290 polymicrobial pulmonary infections. Common co-isolates in pulmonary infections were (36%, 95% CI 24–49%, I 71%), (28%, 95% CI 19–38%, I 44%) and spp. (11%, 95% CI 6–20 %, I 56%), while the prevalence of other co-pathogens did not exceed 5%. Most common co-isolates in bloodstream infections were coagulase-negative (21%, 95% CI 12–34 %, I 84%), (15%, 95% CI 9–26%, I 73%), (12%, 95% CI 6–22%, I 74%), spp. (10%, 95% CI 6–16%, I 42%), spp. (10%, 95% CI 6–16 %, I 38%) and (8%, 95% CI 4–15%, I 58%).

The common co-isolation of certain pathogens (especially ) with ABC suggests potential beneficial between-pathogen interactions, which may have treatment implications for polymicrobial infections and requires further study.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-05-09
2022-05-24
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