1887

Abstract

Zygomycetes have been known to cause life-threatening infections in humans which are often difficult to treat. We present a rare case of cutaneous mucormycosis in a premature neonate admitted with neonatal sepsis and necrotizing fasciitis. He was diagnosed with infection and managed surgically along with Amphotericin B. Low birth weight, prematurity, respiratory distress, administration of corticosteroid and broad spectrum antibiotics were identified as the potential risk factors in this case which had led to the fungal infection. Early diagnosis and prompt management is critical in prevention of morbidity and mortality associated with the disease.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. The Microbiology Society waived the open access fees for this article.
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2022-03-09
2022-05-18
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References

  1. Shah P, Vyas D. A case of otomycosis caused by Lichtheimia corymbifera (syn. Absidia corymbifera, Mycocladus corymbifer) in a healthy immunocompetent individual. Indian J Otol 2011; 17:33 [View Article]
    [Google Scholar]
  2. Oh D, Notrica D. Primary cutaneous mucormycosis in infants and neonates: case report and review of the literature. J Pediatr Surg 2002; 37:1607–1611 [View Article] [PubMed]
    [Google Scholar]
  3. Kumar V, Aggarwal A, Taneja R, Saha SS, Khazanchi RK et al. Primary cutaneous mucormycosis in a premature neonate and its management by tumescent skin grafting. Br J Plast Surg 2005; 58:852–854 [View Article] [PubMed]
    [Google Scholar]
  4. Kaur R, Bala K, Ahuja RB, Srivastav P, Bansal U et al. Primary cutaneous mucormycosis in a patient with burn wounds due to Lichtheimia ramosa . Mycopathologia 2014; 178:291–295 [View Article] [PubMed]
    [Google Scholar]
  5. Hoffmann K, Walther G, Voigt K. Mycocladus vs. Lichtheimia, a correction (Lichtheimiaceae fam. nov., Mucorales, Mucoromycotina). Mycol Res 2009; 113:277–278
    [Google Scholar]
  6. Alastruey-Izquierdo A, Hoffmann K, de Hoog GS, Rodriguez-Tudela JL, Voigt K et al. Species recognition and clinical relevance of the zygomycetous genus Lichtheimia (syn. Absidia pro parte, Mycocladus). J Clin Microbiol 2010; 48:2154–2170 [View Article] [PubMed]
    [Google Scholar]
  7. Sugar AM. Mucormycosis. Clin Infect Dis 1992; 14:S126–S129 [View Article] [PubMed]
    [Google Scholar]
  8. Schrödl W, Heydel T, Schwartze VU, Hoffmann K, Grosse-Herrenthey A et al. Direct analysis and identification of pathogenic Lichtheimia species by matrix-assisted laser desorption ionization-time of flight analyzer-mediated mass spectrometry. J Clin Microbiol 2012; 50:419–427 [View Article] [PubMed]
    [Google Scholar]
  9. Geller JD, Peters MS, Su WP. Cutaneous mucormycosis resembling superficial granulomatous pyoderma in an immunocompetent host. J Am Acad Dermatol 1993; 29:462–465 [View Article] [PubMed]
    [Google Scholar]
  10. Mishra S, Shelly D, Gupta D, Bharadwaj R. Invasive cutaneous mucormycosis in a preterm neonate presenting as a vesicobullous lesion. Indian J Pathol Microbiol 2018; 61:103–105 [View Article] [PubMed]
    [Google Scholar]
  11. Garcia-Hermoso D, Hoinard D, Gantier JC, Grenouillet F, Dromer F et al. Molecular and phenotypic evaluation of Lichtheimia corymbifera (formerly Absidia corymbifera) complex isolates associated with human mucormycosis: rehabilitation of L. ramosa . J Clin Microbiol 2009; 47:3862–3870 [View Article] [PubMed]
    [Google Scholar]
  12. Woo PCY, Lau SKP, Ngan AHY, Tung ETK, Leung S-Y et al. Lichtheimia hongkongensis sp. nov., a novel Lichtheimia spp. associated with rhinocerebral, gastrointestinal, and cutaneous mucormycosis. Diagn Microbiol Infect Dis 2010; 66:274–284 [View Article] [PubMed]
    [Google Scholar]
  13. Mouronte-Roibás C, Leiro-Fernández V, Botana-Rial M, Ramos-Hernández C, Lago-Preciado G et al. Lichtheimia ramosa: a fatal case of mucormycosis. Can Respir J 2016; 2016:2178218 [View Article] [PubMed]
    [Google Scholar]
  14. Alastruey-Izquierdo A, Cuesta I, Walther G, Cuenca-Estrella M, Rodriguez-Tudela JL. Antifungal susceptibility profile of human-pathogenic species of Lichtheimia . Antimicrob Agents Chemother 2010; 54:3058–3060 [View Article] [PubMed]
    [Google Scholar]
  15. Bury D, Tissing WJE, Muilwijk EW, Wolfs TFW, Brüggemann RJ et al. Clinical pharmacokinetics of triazoles in pediatric patients. Clin Pharmacokinet 2021; 60:1103–1147 [View Article] [PubMed]
    [Google Scholar]
  16. Shakoor S, Jabeen K, Idrees R, Jamil B, Irfan S et al. Necrotising fasciitis due to Absidia corymbifera in wounds dressed with non sterile bandages. Int Wound J 2011; 8:651–655 [View Article] [PubMed]
    [Google Scholar]
  17. Bibashi E, de Hoog GS, Pavlidis TE, Symeonidis N, Sakantamis A et al. Wound infection caused by Lichtheimia ramosa due to a car accident. Med Mycol Case Rep 2012; 2:7–10 [View Article] [PubMed]
    [Google Scholar]
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